2021
DOI: 10.1016/j.jep.2020.113553
|View full text |Cite
|
Sign up to set email alerts
|

Kaempferol attenuates streptozotocin-induced diabetic nephropathy by downregulating TRAF6 expression: The role of TRAF6 in diabetic nephropathy

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
22
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 37 publications
(22 citation statements)
references
References 36 publications
0
22
0
Order By: Relevance
“…Moreover, oxidative stress burden was reduced by increased SIRT1 expression after oral administration of formononetin (Oza and Kulkarni 2019). Apigenin was reported to possess substantial anti-inflammatory and antioxidant activity via activation of nuclear factor erythroid 2-related factor 2 and haem oxygenase-1 , while kaempferol was shown to reduce inflammatory and fibrogenic responses in NRK-52E cells induced by high glucose (Luo et al 2021). The present results indicate that TWMM has multiple activities that can improve retinal microvascular function in DR.…”
Section: Construction Of a Compound-target-pathway Networkmentioning
confidence: 56%
See 1 more Smart Citation
“…Moreover, oxidative stress burden was reduced by increased SIRT1 expression after oral administration of formononetin (Oza and Kulkarni 2019). Apigenin was reported to possess substantial anti-inflammatory and antioxidant activity via activation of nuclear factor erythroid 2-related factor 2 and haem oxygenase-1 , while kaempferol was shown to reduce inflammatory and fibrogenic responses in NRK-52E cells induced by high glucose (Luo et al 2021). The present results indicate that TWMM has multiple activities that can improve retinal microvascular function in DR.…”
Section: Construction Of a Compound-target-pathway Networkmentioning
confidence: 56%
“… 2020 ), while kaempferol was shown to reduce inflammatory and fibrogenic responses in NRK-52E cells induced by high glucose (Luo et al. 2021 ). The present results indicate that TWMM has multiple activities that can improve retinal microvascular function in DR.…”
Section: Resultsmentioning
confidence: 99%
“…Luo and colleagues explored the association between the attenuating effect of kaempferol in streptozotocin-induced DN mice and tumour necrosis factor receptor associated factor 6 (TRAF6). They found that kaempferol at a dose of 10 mg/kg significantly impaired kidney damage due to its antioxidant and anti-inflammatory effects, which correlated with a decrease in TRAF6 levels [ 51 ]. A recent study by Sharma indicated that kaempferol can attenuate DN by inhibiting the inflammatory signal mediated by RhoA/Rho kinase, which has been confirmed to have a preventive effect on several enzymes that exert antioxidant and cytoprotective effects.…”
Section: Flavonoids For the Treatment Of Diabetic Nephropathymentioning
confidence: 99%
“… 52 Kaempferol significantly reduced kidney inflammation, fibrosis and dysfunction in mice with streptozotocin-induced diabetic nephropathy. 53 Luteolin was reported to ameliorate glomerular sclerosis and interstitial fibrosis in mice with diabetic nephropathy. 54 More importantly our results suggested that IL6 may serve as a potential target of YQHG against CKD.…”
Section: Discussionmentioning
confidence: 99%