Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

Torun, Ilker; Saglam, Necdet; Özgen, Murat

doi:10.1080/21691401.2016.1192040

Cited by 92 publications

(63 citation statements)

References 28 publications

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“…The spectroscopy results indicated that the intramolecular hydrogen bonding was structured between PE and AgNPs after the formation of P-AgNPs [18]. Surface properties of nanomaterials have an important effect on drug release kinetics [26]. Interestingly, when the results of the size and surface morphology of P-AgNPs compared with the results data of TEM micrograph, the size of P-AgNPs within increased amount of PE decreased from 150.90-47.72 nm, but the size of AgNPs increased from 14.16-16.42 nm.…”

Section: Discussionmentioning

confidence: 99%

Investigation the potential use of silver nanoparticles synthesized by propolis extract as N-acyl-homoserine lactone-mediated quorum sensing systems inhibitor

Torun¹,

Tan²,

Emul³

et al. 2020

Turk J Med Sci

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Background/aim: Quorum sensing (QS) is a chemical communication process that bacteria use to regulate virulence. Inhibition of QS (antiQS) overcomes the pathogenicity of bacteria. Silver nanoparticles (AgNPs) have been used as antimicrobials against pathogens, but have not been used against QS-mediated bacterial infection. Also, studies have been carried out on the inhibitory effects of propolis based structures on pathogen growth, but no studies have been found on their potential use as QS inhibitor. The present study aims to investigate the synthesis and characterization of silver nanoparticles (AgNPs) reduced with propolis extract (P-AgNPs) and evaluation of their antimicrobial and, for the first time, antiQS activity. Materials and methods: P-AgNPs were synthesized using with different volumes (1, 2.5 and 5 mL) of propolis extract (PE) by biological method via reduction of silver nitrate. Synthesized P-AgNPs were characterized in terms of hydrodynamic, chemical, morphological, physical, and antioxidant properties. Disc diffusion and flask incubation assays were used to evaluate the antimicrobial effect against Gram-negative bacteria (Escherichia coli, Proteus mirabilis, Proteus vulgaris, Salmonella typhimurium, Enterobacter aerogenes, Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus, Streptococcus mutans, Bacillus thuringiensis) and QSregulated biofilm activity against biosensor strain Chromobacterium violaceum CV026. Results: AgNPs were successfully synthesized by biological method via PE. The violacein pigment production based on the QS system was greatly inhibited by the P-AgNPs (inhibition zones: 16.22-21.48 mm and violacein inhibition: 63.16 ± 2.4-75.24 ± 3.5 %) without interfering with the growth of bacteria, which is the first report on the antiQS effect of P-AgNPs. Conclusion: Our results suggest that P-AgNPs may be potentially used to inhibit bacterial physiological processes due to the signal molecules regulates important collective behavior of bacteria. The development of such nontoxic biomaterials may have great potential to evaluate for the new medicinal substance that inhibits the pathogenic biofilms.

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Section: Discussionmentioning

confidence: 99%

Investigation the potential use of silver nanoparticles synthesized by propolis extract as N-acyl-homoserine lactone-mediated quorum sensing systems inhibitor

Torun¹,

Tan²,

Emul³

et al. 2020

Turk J Med Sci

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“…However, an increase in inhibition was observed at 7 days post-treatment, compared to active alone [81]. In another trial, kaempferol (another low-soluble fungicide) loaded onto lecithin/chitosan showed 67% inhibition efficacy after 60 days storage on a Fusarium oxysporum-infected Petri dish [85].…”

Section: Nanoparticles As Carriers For Fungicidesmentioning

confidence: 99%

Nanotechnology for Plant Disease Management

et al. 2018

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Each year, 20%–40% of crops are lost due to plant pests and pathogens. Existing plant disease management relies predominantly on toxic pesticides that are potentially harmful to humans and the environment. Nanotechnology can offer advantages to pesticides, like reducing toxicity, improving the shelf-life, and increasing the solubility of poorly water-soluble pesticides, all of which could have positive environmental impacts. This review explores the two directions in which nanoparticles can be utilized for plant disease management: either as nanoparticles alone, acting as protectants; or as nanocarriers for insecticides, fungicides, herbicides, and RNA-interference molecules. Despite the several potential advantages associated with the use of nanoparticles, not many nanoparticle-based products have been commercialized for agricultural application. The scarcity of commercial applications could be explained by several factors, such as an insufficient number of field trials and underutilization of pest–crop host systems. In other industries, nanotechnology has progressed rapidly, and the only way to keep up with this advancement for agricultural applications is by understanding the fundamental questions of the research and addressing the scientific gaps to provide a rational and facilitate the development of commercial nanoproducts.

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“…The use of SACPNs for the encapsulation and delivery of antibacterial agents has received increasing attentions. For instance, kaempferol (KAE) is loaded into SACPNs and compared with pure KAE to determine antifungal activity against the phytopathogenic fungus, as illustrated schematically and shown by the microscopic images in Figure 12(a and b) (Ilk et al, 2017). KAE can be successfully encapsulated in SACPNs with an efficiency of 93.8 ± 4.28% and the generated SACPNs show good physicochemical stability.…”

Section: Antibacterialmentioning

confidence: 99%

Self-Assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery

Gao

Sun

et al. 2020

Drug Delivery

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Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

Cited by 92 publications

References 28 publications

Investigation the potential use of silver nanoparticles synthesized by propolis extract as N-acyl-homoserine lactone-mediated quorum sensing systems inhibitor

Investigation the potential use of silver nanoparticles synthesized by propolis extract as N-acyl-homoserine lactone-mediated quorum sensing systems inhibitor

Nanotechnology for Plant Disease Management

Self-Assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery

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