Kafirin polymer film for enteric coating on HPMC and Gelatin capsules

Lal, Sumit; Tanna, Pooja; Kale, Sandeep; Mhaske, S. T.

doi:10.1007/s10853-016-0637-6

Cited by 22 publications

(8 citation statements)

References 43 publications

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“…The XRD patterns of DDGS kafirin, grain kafirin and zein exhibit two broad peaks at approximately 9° and 20° 2θ (Fig. 3 a), which is consistent with previous XRD investigations of prolamin proteins 20 , 44 . In general, diffraction studies are not “information rich” with respect to determining the structure of prolamins, largely due to a high degree of unordered structure within prolamins, which may be amorphous or nano-crystalline 45 , 46 .…”

Section: Resultssupporting

confidence: 90%

Physicochemical characterisation of kafirins extracted from sorghum grain and dried distillers grain with solubles related to their biomaterial functionality

Shah

Dwivedi

Hackett

et al. 2021

Sci Rep

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Kafirin, the hydrophobic prolamin storage protein in sorghum grain is enriched when the grain is used for bioethanol production to give dried distillers grain with solubles (DGGS) as a by-product. There is great interest in DDGS kafirin as a new source for biomaterials. There is however a lack of fundamental understanding of how the physicochemical properties of DDGS kafirin having been exposed to the high temperature conditions during ethanol production, compare to kafirin made directly from the grain. An understanding of these properties is required to catalyse the utilisation of DDGS kafirin for biomaterial applications. The aim of this study was to extract kafirin directly from sorghum grain and from DDGS derived from the same grain and, then perform a comparative investigation of the physicochemical properties of these kafirins in terms of: polypeptide profile by sodium-dodecyl sulphate polyacrylamide gel electrophoresis; secondary structure by Fourier transform infra-red spectroscopy and x-ray diffraction, self-assembly behaviour by small-angle x-ray scattering, surface morphology by scanning electron microscopy and surface chemical properties by energy dispersive x-ray spectroscopy. DDGS kafirin was found to have very similar polypeptide profile as grain kafirin but contained altered secondary structure with increased levels of β-sheets. The structure morphology showed surface fractals and surface elemental composition suggesting enhanced reactivity with possibility to endow interfacial wettability. These properties of DDGS kafirin may provide it with unique functionality and thus open up opportunities for it to be used as a novel food grade biomaterial.

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Section: Resultssupporting

confidence: 90%

Physicochemical characterisation of kafirins extracted from sorghum grain and dried distillers grain with solubles related to their biomaterial functionality

Shah

Dwivedi

Hackett

et al. 2021

Sci Rep

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show abstract

“…The XRD patterns of DDGS ka rin, grain ka rin and zein exhibit two broad peaks at approximately 9 and 20° 2θ (Fig. 3A), which is consistent with previous XRD investigations of prolamin proteins 16,34 . In general, diffraction studies are not "information rich" with respect to determining the structure of prolamins, largely due to a high degree of unordered structure within prolamins, which may be amorphous or nano-crystalline 35,36 .…”

Section: Characterising Protein Diffraction Patterns Using X-ray Diffsupporting

confidence: 90%

Physicochemical characterisation of kafirins extracted from sorghum grain and dried distillers grain with solubles related to their biomaterial functionality

Shah

Dwivedi

Hackett

et al. 2021

Preprint

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Kafirin, the hydrophobic prolamin storage protein in sorghum grain is enriched when the grain is used for bioethanol production to give dried distillers grain with solubles (DGGS) as a by-product. There is great interest in DDGS kafirin as a new source for biomaterials. There is however a lack of fundamental understanding of how the physicochemical properties of DDGS kafirin having been exposed to the high temperature conditions during ethanol production, compare to kafirin made directly form the grain. An understanding of these properties is required to catalyse the utilisation of DDGS kafirin for biomaterial applications. The aim of this study was to extract kafirin directly from sorghum grain and from DDGS derived from the same grain and, then perform a comparative investigation of the physicochemical properties of these kafirins in terms of: polypeptide profile by sodium-dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE); secondary structure by Fourier transform infra-red (FTIR) spectroscopy and x-ray diffraction (XRD), self-assembly behaviour by small-angle x-ray scattering (SAXS), surface morphology by scanning electron microscopy (SEM) and surface chemical properties by energy dispersive x-ray spectroscopy (EDS). DDGS kafirin was found to have very similar polypeptide profile as grain kafirin but contained altered secondary structure with increased levels of β-sheets. The structure morphology showed surface fractals and surface elemental composition suggests enhanced reactivity with possibility to endow interfacial wettability. These properties of DDGS kafirin may provide it with unique functionality and thus open up opportunities for it to be used as a novel food grade biomaterial.

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“…Compared with a gelatine solution with a viscosity of 25.60 cP at 25.5 °C [ 44 ], a carrageenan-based solution has good potential for use as a drug-delivery system. Another candidate is HPMC, with its hydrophilic nature that helps form a gel with very low viscosities of ≤100.00 cP ( Table 7 ) [ 43 ], which enables immediate release from the pins in the dipping method [ 62 ].…”

Section: Hard Capsules: Preparation and Characterisationmentioning

confidence: 99%

Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review

et al. 2021

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Intense efforts to develop alternative materials for gelatine as a drug-delivery system are progressing at a high rate. Some of the materials developed are hard capsules made from alginate, carrageenan, hypromellose and cellulose. However, there are still some disadvantages that must be minimised or eliminated for future use in drug-delivery systems. This review attempts to review the preparation and potential of seaweed-based, specifically carrageenan, hard capsules, summarise their properties and highlight their potential as an optional main component of hard capsules in a drug-delivery system. The characterisation methods reviewed were dimensional analysis, water and ash content, microbial activity, viscosity analysis, mechanical analysis, scanning electron microscopy, swelling degree analysis, gel permeation chromatography, Fourier-transform infrared spectroscopy and thermal analysis. The release kinetics of the capsule is highlighted as well. This review is expected to provide insights for new researchers developing innovative products from carrageenan-based hard capsules, which will support the development goals of the industry.

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Kafirin polymer film for enteric coating on HPMC and Gelatin capsules

Cited by 22 publications

References 43 publications

Physicochemical characterisation of kafirins extracted from sorghum grain and dried distillers grain with solubles related to their biomaterial functionality

Physicochemical characterisation of kafirins extracted from sorghum grain and dried distillers grain with solubles related to their biomaterial functionality

Physicochemical characterisation of kafirins extracted from sorghum grain and dried distillers grain with solubles related to their biomaterial functionality

Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review

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