Musi River plays a significant role in the history and development of Palembang. Historically, the river had been used for settlement, trading, and transport activities. This phenomenon established the riparian culture that is deeply associated with the native residents who had been attached to the Musi River. However, the essential meaning of the river as a place has begun to fade because of the rapid growth of land transportation. People have shifted their water-based activities to land. This study is intentioned to capture the meaning of Musi riparian culture, which covers 16 Ilir Market area, the oldest trade center in Palembang with significant historic characteristics. By architectural phenomenology approach, this study is aimed to capture the genius loci in the area. Using qualitative research methods through the "genius loci" framework will be traced to the existence of the Musi riparian area. The results show that interactions between humans and rivers generate the spirit of this place, such as various activities, diverse ethnicity, and significant cultural history narration. Thus interaction is essential to maintain the unique characteristics of Musi riparian culture in modern times.