Kalanchoe tubiflora extract inhibits cell proliferation by affecting the mitotic apparatus

Hsieh, Yi-Jen; Yang, Ming-Yeh; Leu, Yann‐Lii; Chen, Chinpiao; Wan, Chin-Fung; Chang, Meng-Ya; Chang, Chih-Jui

doi:10.1186/1472-6882-12-149

Cited by 21 publications

(14 citation statements)

References 64 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, higher activity was observed for the extract against human papillomavirus (HPV), which plays a pivotal role in the development of cervical cancer [87]. The butanol-soluble fraction of an ethanolic extract of fresh B. delagoense plants showed antiproliferative activity [88] in several cell lines via a modulation of the mitotic cell division. More recently, the water-soluble fraction of the same extract was shown to cause cell cycle arrest, and to induce senescence in lung cancer A549 cells.…”

Section: Cytotoxic and Antitumor Promoting Activitymentioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

View full text Add to dashboard Cite

ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

show abstract

Section: Cytotoxic and Antitumor Promoting Activitymentioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Clinical studies have suggested relationships between visceral cancers, heart diseases, and abnormalities of the tongue and its coating [2-4]. However, the current practice in TCM is mainly subjective, and the quality of the visual inspection varies among medical professionals.…”

Section: Introductionmentioning

confidence: 99%

Computerized tongue image segmentation via the double geo-vector flow

Shi

et al. 2014

Chin Med

View full text Add to dashboard Cite

BackgroundVisual inspection for tongue analysis is a diagnostic method in traditional Chinese medicine (TCM). Owing to the variations in tongue features, such as color, texture, coating, and shape, it is difficult to precisely extract the tongue region in images. This study aims to quantitatively evaluate tongue diagnosis via automatic tongue segmentation.MethodsExperiments were conducted using a clinical image dataset provided by the Laboratory of Traditional Medical Syndromes, Shanghai University of TCM. First, a clinical tongue image was refined by a saliency window. Second, we initialized the tongue area as the upper binary part and lower level set matrix. Third, a double geo-vector flow (DGF) was proposed to detect the tongue edge and segment the tongue region in the image, such that the geodesic flow was evaluated in the lower part, and the geo-gradient vector flow was evaluated in the upper part.ResultsThe performance of the DGF was evaluated using 100 images. The DGF exhibited better results compared with other representative studies, with its true-positive volume fraction reaching 98.5%, its false-positive volume fraction being 1.51%, and its false-negative volume fraction being 1.42%. The errors between the proposed automatic segmentation results and manual contours were 0.29 and 1.43% in terms of the standard boundary error metrics of Hausdorff distance and mean distance, respectively.ConclusionsBy analyzing the time complexity of the DGF and evaluating its performance via standard boundary and area error metrics, we have shown both efficiency and effectiveness of the DGF for automatic tongue image segmentation.

show abstract

“…Disturbed metaphase may be the result of disturbances in the spindle apparatus or due to inhibition of spindle formation (Hsieh et al 2012;Cuyacot et al 2014;Tripathy and Rao 2015). Adam and El-Ashry (2010) attributed macro and micro cells to the failure of normal organization and function of spindle apparatus.…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity assessment of two common curing weeds: Hyptis suaveolens (L.) Poir. and Leucas indica (L.) R. Br.

Sumitha

Thoppil

2015

Cytotechnology

View full text Add to dashboard Cite

Hyptis suaveolens and Leucas indica, two common weeds were selected for the present study, to reveal their probable cytotoxic potential. The meristematic root tips of Allium cepa were used for testing the cytotoxic property of the aqueous leaf extracts containing both polar and non-polar compounds, and that containing polar compounds alone, at different concentrations (0.125, 0.25, 0.5, 1 and 2 %) and at different time durations, using distilled water as negative control. Mitotic squash preparations were made using a standard protocol. The mitotic index of the treated root tip cells was found to be decreasing and the abnormality percentage was found to be increasing with increase in extract concentration when compared with the control. Maximum cytotoxicity was observed in the extract containing both polar and non-polar compounds. Both the tested plants were found to be cytotoxic. The abnormalities noticed were of both clastogenic (nuclear lesions, nuclear fragmentation, etc.) and non-clastogenic (aberrant cell wall formation at cytokinesis, ball metaphase, etc.) types. Both plant extracts were found to significantly (P \ 0.05) inhibit root growth of Allium cepa with an EC 50 value of 1.92 % (R 2 = 0.594) for Hyptis and 1.58 % (R 2 = 0.757) for Leucas. The results were also analysed statistically by using analysis of variance followed by appropriate post hoc tests. These two weeds are aromatic plants comprising of essential oils that are volatile, natural complex compounds characterized by a strong odour and formed as secondary metabolites. In nature, essential oils play an important role in the protection of the plants as insecticides by reducing their appetite for such plants. When specifically targeted the concept of effectively exploiting these weeds for the formulation of herbal insecticides/ pesticides may be possible in the near future.

show abstract

Kalanchoe tubiflora extract inhibits cell proliferation by affecting the mitotic apparatus

Cited by 21 publications

References 64 publications

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Computerized tongue image segmentation via the double geo-vector flow

Genotoxicity assessment of two common curing weeds: Hyptis suaveolens (L.) Poir. and Leucas indica (L.) R. Br.

Contact Info

Product

Resources

About