Kalopanaxsaponins A and B Isolated from <i>Kalopanax pictus</i> Ameliorate Memory Deficits in Mice

Joh, Eun-Ha; Lee, Inah; Kim, Dong-Hyun

doi:10.1002/ptr.3596

Cited by 31 publications

(18 citation statements)

References 28 publications

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“…Further, p-CREB may play a critical role in the adaptive neuronal responses underlying learning and memory function [55]. As had been reported previously, our present study showed that CREB phosphorylation in the hippocampus was reduced by scopolamine [54][55][56]. Meanwhile, Pal-5HT at 0.5 or 1 mg/kg significantly prevented against the reduction in scopolamine-induced expression of p-CREB.…”

Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 75%

N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice

Min

Doo

Son

et al. 2015

Chemico-Biological Interactions

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Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 75%

N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice

Min

Doo

Son

et al. 2015

Chemico-Biological Interactions

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“…A similar study showed that kalopanaxsaponins A and B, types of triterpenoid saponins that have similar structures to β-amyrin (geminal methyls in the E ring), also inhibited AChE activity and improved memory function in the scopolamine-induced amnesic model. 23) Therefore, we assume that the different effects of α-amyrin and β-amyrin on AChE may result from these distinct structures. Moreover, the memory-ameliorating effects of α-amyrin on scopolamine-induced memory impairments may be not resulted from its AChE inhibitory activity.…”

Section: Discussionmentioning

confidence: 99%

Amyrin Attenuates Scopolamine-Induced Cognitive Impairment in Mice

Park

Ahn

et al. 2014

Biological & Pharmaceutical Bulletin

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Alzheimer's disease, a neurodegenerative disorder, is characterized by progressive cognitive impairment associated with the disruption of cholinergic neurotransmission. The aim of the present study was to evaluate the effect of α-or β-amyrin, a type of pentacyclic triterpene, on the cognitive impairment induced by scopolamine, a muscarinic acetylcholine receptor antagonist. To measure the abilities of various types of learning and memory, we conducted step-through passive avoidance task. Scopolamine induced deficits in learning and memory processes in mice, which were antagonized by a single administration of α-amyrin (2 or 4 mg/kg) or β-amyrin (4 mg/kg), respectively. Additionally, in vitro analysis revealed that acetylcholinesterase activity was inhibited by β-amyrin, but not by α-amyrin. Furthermore, Western blot analysis revealed that the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β) were significantly enhanced by a single administration of α-and β-amyrin in the hippocampus. Finally, the memory ameliorating effects of α-or β-amyrin on the scopolamine-induced cognitive impairments were significantly blocked by ERK inhibitor U0126. The present study suggests that α-and β-amyrin may ameliorate the cognitive impairment induced by hypocholinergic neurotransmission via the activation of ERK as well as GSK-3β signaling.

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“…To ensure the anticolitic effect of KP BuOH fraction, we isolated kalopanaxsaponin B, a main constituent of KP BuOH fraction (Joh et al ., 2012), in TNBS-induced colitic mice (Fig. 5).…”

Section: Resultsmentioning

confidence: 99%

Kalopanaxsaponin B Ameliorates TNBS-Induced Colitis in Mice

Jeong¹,

Jang²,

Joh³

et al. 2012

Biomolecules and Therapeutics

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The stem-bark of Kalopanax pictus (KP, family Araliaceae), of which main constituent is kalopanaxsaponin B, has been used for asthma, rhinitis, and arthritis in Chinese traditional medicine. To clarify anticolitic effect of KP, we examined anti-inflammatory effect of KP extract and kalopanaxsaponin B in lipopolysaccharide (LPS)-stimulated peritoneal macrophage and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitic mice. Of KP extracts, KP BuOH-soluble fraction most potently inhibited LPS-induced IL-1β, IL-6 and TNF-α expression, as well as NF-κB activation. However, KP BuOH fraction increased IL-10, an anti-inflammatory cytokine. KP BuOH fraction also inhibited colon shortening and myeloperoxidase activity in TNBS-induced colitic mice. KP BuOH fraction also potently inhibited the expression of the pro-inflammatory cytokines, IL-1β, IL-6 and TNF-α as well as the activation of NF-κB. Kalopanaxsaponin B, a main constituent of KP, inhibited TNBS-induced colonic inflammation, including colon shortening, and TNBS-increased myeloperoxidase activity pro-inflammatory cytokine expression and NF-κB activation in mice. Based on these findings, KP, particularly its main constituent, kalopanaxsaponin B, may ameliorate colitis by inhibiting NF-κB pathway.

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Kalopanaxsaponins A and B Isolated from Kalopanax pictus Ameliorate Memory Deficits in Mice

Cited by 31 publications

References 28 publications

N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice

N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice

Amyrin Attenuates Scopolamine-Induced Cognitive Impairment in Mice

Kalopanaxsaponin B Ameliorates TNBS-Induced Colitis in Mice

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