1996
DOI: 10.1002/hep.510240624
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Kan–1 (Bile Acid Coa:Amino Acid N –Acyltransferase) Messenger Rna As A Novel Predictive Indicator for Prognosis of Hepatocellular Carcinoma Patients After Partial Hepatectomy

Abstract: Hepatocellular carcinoma (HCC) is one of the most commonWe identified kan-1 complementary DNA (cDNA), the cancers in the Orient and in South Africa. Over the past 10 sequence of which is identical to bile acid CoA:amino years, great progress has been made in the diagnosis and acid N-acyltransferase (BAT), a liver enzyme that catatreatment of HCC patients, and consequently, the number lyzes the conjugation of bile acids with glycine or tauof resectable cases has increased. 3,4 However, despite this rine. Kan-1(… Show more

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“…Other downregulated genes included inhibitors of nucleotide signaling (Gdi2), immune system, and host defense response genes (CD3, Fcgr2b), and a form of super-oxide dismutase (SOD3). Bat, a potential marker for the prognosis of HCC, was also decreased in tumor samples (Furutani et al, 1996). The sixth cluster (PAM6) contained genes that were downregulated in non-tumor, adjacent tissues of Txnip-deficient mice ( Figure 5).…”
Section: Preneoplastic Changes In Txnip-deficient Liversmentioning
confidence: 97%
“…Other downregulated genes included inhibitors of nucleotide signaling (Gdi2), immune system, and host defense response genes (CD3, Fcgr2b), and a form of super-oxide dismutase (SOD3). Bat, a potential marker for the prognosis of HCC, was also decreased in tumor samples (Furutani et al, 1996). The sixth cluster (PAM6) contained genes that were downregulated in non-tumor, adjacent tissues of Txnip-deficient mice ( Figure 5).…”
Section: Preneoplastic Changes In Txnip-deficient Liversmentioning
confidence: 97%
“…Massive and uncontrollable recurrence of HCC tends to occur in the group of patients who have low BAAT expression. BAAT was also found to be a reliable indicator for both survival and recurrence in HCC patients [18]. These evidences suggest that gene BAAT may play a role in the recurrence of HCC.…”
Section: Predicting Hcc Genes From Human Ppis Networkmentioning
confidence: 75%
“…It is mainly expressed in fully differentiated and quiescent liver cells. Researchers have found that low expression of BAAT is significantly associated with a decreased probability of survival in HCC patients [18]. Massive and uncontrollable recurrence of HCC tends to occur in the group of patients who have low BAAT expression.…”
Section: Predicting Hcc Genes From Human Ppis Networkmentioning
confidence: 99%