Kann man dem Clearance-Begriff einen solchen der “Entrance” gegenüberstellen?

Dost, F. H.

doi:10.1007/bf02432776

Cited by 8 publications

(2 citation statements)

References 20 publications

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“…The 1930s brought the two-compartment models and the key concepts of the mean residence time, clearance, , and the volume of distribution . The one-compartment model and two-compartment models were later applied to the disposition kinetics of drugs – and radioactive substances – in the organisms. Since the 1950s, kinetic models of multiple dosage regimens ,– have had a broad impact on how therapeutic interventions are performed.…”

Section: Disposition Of Chemicalsmentioning

confidence: 99%

Modeling Kinetics of Subcellular Disposition of Chemicals

Baláž

2009

Chem. Rev.

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Section: Disposition Of Chemicalsmentioning

confidence: 99%

Modeling Kinetics of Subcellular Disposition of Chemicals

Baláž

2009

Chem. Rev.

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“…Just 100 years ago Murray Lyon published a paper entitled “The absorption of adrenalin” [ 1 ] where he derived the biexponential function for the first time in pharmacology. Dost was probably not aware of this work when he applied this model (later known as Bateman function) to oral absorption [ 2 ]. Now it is the most popular model in pharmacokinetics and has been used in more than 3000 population pharmacokinetic studies.…”

Section: Introductionmentioning

confidence: 99%

Is the One-Compartment Model with First Order Absorption a Useful Approximation?

Weiss

2023

Pharm Res

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Purpose The one-compartment model with first order absorption (ka1C) has been extensively used to fit oral data. But when the disposition parameters of the drug are not available, the bias in the parameter estimates remains unclear. In this paper, the effect of potential misspecification of the area under the curve (AUC) and the mean absorption time (MAT) was evaluated for three relatively slowly absorbed drugs/formulations. Methods Assuming a three-compartment disposition model with an input (absorption) rate described as a sum of two inverse Gaussian functions (2IG3C) as the true model, the deviations of AUC and MAT estimated with simpler models were analyzed. Simpler models, as the ka1C model (Bateman function), the one-compartment model with IG input function (IG1C) and the gamma density function were fitted to the oral data alone, and compared to the fits obtained with the 2IG3C model which also uses the 3C disposition parameters of the drug. Data from pharmacokinetic studies of trospium, propiverine and ketamine in healthy volunteers were analyzed using a population approach. Results The Bateman function (ka1C) allowed a robust estimation of the population mean AUC, but the individual estimates were highly biased. It failed in evaluating MAT. The simple alternative models did not improve the situation. Conclusions The Bateman function appears to be useful for estimating the population mean value of AUC after oral administration. The results reemphasize the fact that insight into the absorption process can be only gained when also intravenous reference data are available.

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