Kaposi’s sarcoma: An unusual penile lesion in a HIV negative patient

Abstract

Kaposi's sarcoma (KS) of the penis is a very rare lesion and it is usually observed in HIV-infected patients. We introduce a case of KS of the penis in a 75 years old HIV negative patient with a peripheral T-cell lymphoma. He came to our attention with a painful ulcerated red lesion on the glans that stretched from the urethral meatus to the coronal skin. This lesion was found to be a KS balanopreputial in the classical variant. Penile KS must be included in the differential diagnosis of genital diseases especially when the clinical features of the lesion are aspecific and diagnosis can be made histologically by performing a biopsy.KEY WORDS: Kaposi sarcoma; Penile lesion; HIV negative; HHV-8; T-cell lymphoma. The abdominal CT scan showed no inguinal lymph nodes or other suspected lesions. Due to an extended lesion and to the absence of a clear diagnose it was decided to perform a glansectomy. The histopathology examination described a classical balanopreputial KS. Six months later the patient was negative for local recurrence but a secondary gastrointestinal lesion was detected during a whole body CT scan and a gastric biopsy was performed. The patient is currently under therapy with interferon.

Primary penile Kaposi’s sarcoma in HIV-seronegative patient: a case report and literature review

“…Other approaches described in literature could include radiotherapy (25,29,37,42), subtotal circumcision associated with biopsy (45), cryotherapy associated with 5% Imiquimod cream (21), excisional biopsy associated with IFNα (32), biopsy with chemotherapy (39), CO2 (48), biopsy with radiotherapy (46). Furthermore, in five cases no therapy was performed (22,23,33,34), two of them for the spontaneous regression of the disease (33,34). The clinical course of primary penile KS is variable and no standardized follow-up exists to date.…”

Hiv Negative Penile Kaposi's Sarcoma In Circumcised Men

“…hypertensive; and 3 years ago, he was diagnosed as T cell lymphoma and was treated with chemotherapy. 7 Penislimited KS in patients with AIDS is found in less than 3% of the patients; and in 20% of the cases, genital lesions are a part of the systematic disease. 8 Lesions on the penis can be at preputium, coronal sulcus, glans and rarely at the shaft.…”

Tumor Lysis Syndrome: Introduction of a Cutaneous Variant and a New Classification System

“…The key feature is necrosis and ulceration of the skin tumors in the absence of therapy. In addition, albeit rare to date, cases suggestive of this diagnosis have been observed in patients with untreated solid tumors (such as melanoma, breast cancer, and Kaposi sarcoma) [7,[27][28][29][30][31][32][33][34][35][36][37][38][39].…”

“…However, it remains unclear if some of these cases were accompanied by rapid tumor death, a key feature of cutaneous tumor lysis syndrome [7,[27][28][29][30][31][32][33][34][35][36][37][38][39]. Solid tumors: In addition to patients with Kaposi sarcoma, characteristics possibly compatible with solid tumor-associated spontaneous (idiopathic) cutaneous tumor lysis syndrome have also been reported in patients with other solid tumors (Table 4) [7,[35][36][37][38][39]. For example, a 79-year-old man with metastatic melanoma in whom the phenomenon was referred to as giant centrifugal and necrotizing cutaneous metastases of melanoma [35].…”