Kaposi sarcoma: review and medical management update

Fatahzadeh, Mahnaz

doi:10.1016/j.tripleo.2011.05.011

Cited by 86 publications

(51 citation statements)

References 159 publications

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“…The dismal clinical status with multiorgan failure precluded safe administration of chemotherapy in our patient. Ten to 30% of patients may develop paradoxical worsening of existing infections and malignancies following successful immune restoration with HAART, a phenomenon called immune reconstitution inflammatory syndrome (IRIS) 3,13. It is unlikely that our patient had developed IRIS as his KS was already advanced prior to initiating HAART and repeat viral load test failed to suggest significant immune reconstitution within the timeframe of his death.…”

Section: Discussionmentioning

confidence: 93%

“…HAART remains the mainstay of treatment and represents the first-line therapy for limited cutaneous and slowly progressive disease. HAART with concomitant systemic chemotherapy with drugs like liposomal doxorubicin is indicated in selected patients with visceral, disseminated, or rapidly progressive disease 1,3,13. The dismal clinical status with multiorgan failure precluded safe administration of chemotherapy in our patient.…”

Section: Discussionmentioning

confidence: 96%

“…To date, there is no curative treatment for KS, and the goal of therapy is symptom palliation 13. Management of AIDS-related KS is based on the ACTG staging.…”

Section: Discussionmentioning

confidence: 99%

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Kaposi's Sarcoma of the Rectum in a Homosexual Male with HIV-AIDS

Kumar

Nautsch

2016

ACG Case Reports Journal

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Visceral involvement in AIDS-related Kaposi’s sarcoma is common, but it is rarely seen in the absence of cutaneous disease. Most patients with gastrointestinal tract Kaposi’s sarcoma remain asymptomatic and are often diagnosed on endoscopy or autopsy. We report a case of a 24-year-old homosexual man who presented with rectal pain and bleeding and was found to have skin-sparing, disseminated Kaposi’s sarcoma with rectum, liver, lungs, and lymph node involvement. Despite treatment with highly active anti-retroviral therapy, he developed multiorgan failure resulting in death.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 96%

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Kaposi's Sarcoma of the Rectum in a Homosexual Male with HIV-AIDS

Kumar

Nautsch

2016

ACG Case Reports Journal

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“…On the other hand, fish bones are the most common cause of these lesions in the tonsil, soft palate, tongue base, posterior pharyngeal wall and upper oesophagus. Oral granuloma due to on FBR is frequently accompanied at early stages by pain, swelling, local infection around the foreign body and history of oral trauma [17, 19]. …”

Section: Discussionmentioning

confidence: 99%

A Gray-purple Mass on the Floor of the Mouth: Gigantic Mucogingival Pyogenic Granuloma in a Teenage Patient

Brunet‐Llobet

Miranda‐Rius²,

Lahor-Soler³

et al. 2014

TODENTJ

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Pyogenic granuloma is defined as a benign neoplasm of vascular phenotype. This case describes the clinical and histopathological features of a gigantic mucogingival pyogenic granuloma, in a 14-year-old healthy black boy. This exophytic gray-purple mass, related to a toothpick injury, had more than twelve-month evolution on the anterior mandible involving lingual area besides to the floor of the mouth pressing the right salivary duct. Conservative excision was performed, followed by uncomplicated healing with no recurrence in two years. The histopathological examination reported a pyogenic granuloma (lobular capillary haemangioma). The authors provide a discussion of the presurgical differential diagnosis of the lesion. This case report presents an extremely uncommon location of a gigantic pyogenic granuloma, involving mucogingival complex and affecting the salivary outflow. This clinical manuscript may shed light on the controversies about possible mechanisms inducing oral pyogenic granuloma.

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“…human herpes viruses (HHV), in the pathogenesis of AK are so far controversial. HHV8 is considered the infective agent of Kaposi sarcoma [9], which is a malignancy of lymphatic endothelial cells [10]. Classic Kaposi sarcoma is quite common in the Mediterranean area [11] and in Sardinia in particular.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a Film-Forming Medical Device Containing Piroxicam and Sun Filters in the Treatment of Multiple Actinic Keratosis Lesions in a Subject with a History of Kaposi Sarcoma

2016

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Actinic keratosis (AK) is considered a premalignant form of skin cancer due to chronic sun exposure. In addition, human papilloma virus (HPV) has been advocated a role in the pathogenesis of this clinical condition. HPV proteins (mainly E6 and E7) seem to act synergistically with ultraviolet (UV) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after UV damage. Data regarding the involvement of other viruses, i.e. human herpes viruses (HHV), in the pathogenesis of AK are so far controversial. HHV8 is considered the infective agent involved in the development of Kaposi sarcoma. Some experimental data have shown that AK lesions carry HHV8 in more than 30% of the bioptic samples. Topical piroxicam was shown to be effective in the treatment of AK. In addition, the molecule shows antiviral action against HPV and HHV8. Here, we report the efficacy of a medical device containing a film-forming substance (polyvinyl alcohol), chemical and physical sun filters (SPF 50+), and 0.8% piroxicam (Actixicam^TM, Difa Cooper; ACTX) in the treatment of multiple scalp AK lesions, unresponsive to other treatments, in a subject with Kaposi sarcoma and a history of severe contact dermatitis. The subject presented with severe involvement of the scalp, with multiple hypertrophic AK lesions. Previous lesion-directed and field-targeted treatments have not been effective. The subject was treated with ACTX applied twice daily on the affected scalp. Relevant clinical improvement was observed as soon as 1 month of therapy. Complete clinical resolution of all scalp lesions was observed after 3 months of treatment. The product was well tolerated.

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Kaposi sarcoma: review and medical management update

Cited by 86 publications

References 159 publications

Kaposi's Sarcoma of the Rectum in a Homosexual Male with HIV-AIDS

Kaposi's Sarcoma of the Rectum in a Homosexual Male with HIV-AIDS

A Gray-purple Mass on the Floor of the Mouth: Gigantic Mucogingival Pyogenic Granuloma in a Teenage Patient

Efficacy of a Film-Forming Medical Device Containing Piroxicam and Sun Filters in the Treatment of Multiple Actinic Keratosis Lesions in a Subject with a History of Kaposi Sarcoma

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