Kaposiform haemangioendothelioma associated with Kasabach‐Merritt syndrome

Kaposiform Hemangioendothelioma in Adults:Clinicopathologic and Immunohistochemical Analysis of Three Cases

“…18 In addition, KHE is composed of mature endothelial cells showing immunopositivity for vascular markers, actin-positive pericytes, and spindle-shaped stromal cells, which stain only focally p o s i t i v e for CD34 and are n e g a t i v e for factor VHI-related antigen. 19 The spindle cells in Kaposi's sarcoma, however, are characterized by constant and reproducible immunopositivity for CD34, are actin negative, and are believed to represent immature endothelial cells. 20 Spindle cell hemangioendothelioma is a further differential diagnosis for KHE occurring in adults.…”

Acute Onset of Coagulopathy in a Patient with Kasabach-Merritt Syndrome following Transurethral Resection of Bladder Tumor

“…In a recent case, fibrin and thrombin were observed within neoplastic vascular vessels. It is speculated that the tendency to hemorrhage and thrombocytopenia could be attributed to the trapping of platelets and the activation of coagulation pathways within the tumor [2]. In addition, the end result of these processes, DIC and microvascular coagulation, is occasionally one of the pathophysiological developments of endotoxin-induced sepsis [3,4].…”

Kasabach-Merritt-Syndrom bei Riesenhämangiom der Leber Ein Fallbericht

“…Es wird dabei spekuliert, dass eine Aktivierung der Gerinnung in dem Tumor mit nachfolgend systemischer Hyperfibrinolyse zusammen mit einem "Trapping" der Thrombozyten in den pathologischen Gefäßen zur Blutungsneigung führt [22,23]. Wir beschreiben hier einen Fall, in dem eine präoperative, niedrig dosierte Heparinisierung zu einer weitgehenden Normalisierung der Blutgerinnung führte.…”