Kaposiform hemangioendothelioma: A locally aggressive vascular tumor

Case Report: Kaposiform Hemangioendothelioma in Multiple Spinal Levels Without Skin Changes

“…10, 11). Discussion KH is a rare, locally aggressive endothelial-derived spindle cell neoplasm that occurs nearly exclusively during childhood [1]. Although it can be locally aggressive, KH has little metastatic potential [47], although death has resulted from severe coagulopathy associated with KMP [18,39,47].…”

Benign Cutaneous Vascular Tumors of Infancy

“…53 Systemic corticosteroids alone have been beneficial in some patients, though most reports cite steroid use in combination with other therapeutic modalities. 94,95 Interferon alfa is useful for treating both the tumor and associated KMS, and is effective in about 50% of children. [96][97][98] Multimodal intervention has also been successful using embolization, interferon, cyclophosphamide, ⑀-aminocaproic acid, and compression therapy.…”

Kaposiform Hemangioendothelioma With Kasabach-Merritt Syndrome

“…8 Therefore, other different treatments (or combinations) have been described. Ticlopidine in combination with aspirin, heparin, low molecular weight heparin, embolization, and radiation therapy has been described with variable outcome and limited success.…”

“…Ticlopidine in combination with aspirin, heparin, low molecular weight heparin, embolization, and radiation therapy has been described with variable outcome and limited success. [8][9][10][11][12] Systemic steroids and interferon-a are suggested but with marginal success rates of respectively, 10 and 50% to 60%, with a significant risk of neurotoxicity because of interferon. 2 Currently, vincristine is mainly used for patients with KHE often combined with corticosteroids.…”