Karakteristik Histopatologik dan Imunofenotipik Kanker Payudara di Rumah Sakit Cipto Mangunkusumo Jakarta, Indonesia

Abstract

<p>Introduction: Breast cancer can be classified into luminal A, luminal B, Her2+, dan basal-like molecular subtype according to genetic profile and immunophenotype. The aim of this study is to assess histopathologic and immunophenotype characteristics of breast cancer in Cipto Mangunkusumo Hospital Jakarta, Indonesia.<br />Material and methods: This study is a cross-sectional retrospective study. The sample was 2632 breast cancer case in Department of Anatomical Pathology Cipto Mangunkusumo Hospital from the year 2011 until 2015. ER, PR, Her2, Top2 α, and Ki67 immunohistochemical stain was then grouped into luminal A (ER+/PR+/Her2-/Ki67<20%) subtype, luminal B (ER+/PR+/Her2-/Ki67≥20%) subtype, Her2+ (ER-/PR-/Her2+) subtype, and basal-like (ER-/PR-/Her2-) subtype. Kendall’s Tau analysis was done to assess association between sample characteristics and molecular subtype, association between top2α positive and molecular subtype.<br />Result: The most prevalent to the less prevalent breast cancer molecular subtype was luminal B (43,9%), Her2+ (14,6%), luminal A (14,0%), and basal-like (11,3%). There was a significant association between the tumor stage and breast cancer subtype (p=0,0001). There is also a significant association between Top2α expression and molecular subtype (p=0,0001).<br />Conclusion: The most prevalent breast cancer molecular subtype was luminal B. There was an association between breast cancer molecular subtype and a higher degree and Top2α expression.</p>

Profile of Breast Cancer Patients on Estrogen Receptor Expression in RSUD. Dr. Pirngadi Medan 2018-2019

“…Cipto Mangunkusumo who showed that based on the histopathological grade, patients with moderate grade (grade 2) were found more often, namely 1053 cases (40%) compared to patients with low and high malignancy degrees. [31] The results of this study are also in line with research conducted at RSUD Dr. Moewardi Surakarta which shows that of the threegrading histopathology, each of them had negative estrogen receptor expression which was mostly found compared to positive estrogen receptor expression. [30] According to the researcher's assumptions, patients in RSUD.…”

Subtipe Molekuler Kanker Payudara di RSUD Madiun dan Hubungannya dengan Grading Histopatologi

“…Di Rumah Sakit Cipto Mangunkusoma Jakarta, pada tahun 2015 menunjukkan paling banyak adalah tipe luminal B (43,9%), diikuti HER2 (14,6%), luminal A (14,0%), dan basal-like (11,3%). 12 Sedangkan di Rumah Sakit Sanglah Denpasar, pada tahun 2012 menunjukkan terbanyak adalah tipe luminal A. Subtipe luminal A/ subtipe basal-like/triple negative (37,4%), diikuti HER-2 positif (15,6%) dan paling sedikit luminal B (9,5%). 13 Suptipe molekuler kanker payudara bisa jadi berbeda bahkan pada sesama orang Asia.…”

“…23 Tipe histopatologi terbanyak di RS Madiun adalah karsinoma duktal invasif, dan hal yang sama juga ditemukan di RS Arifin Ahmad, Riau; RSCM, Jakarta; dan RS Kariadi, Semarang. 12,18,24 Secara global subtipe histologi ini adalah yang paling umum yaitu sampai 75% dari semua karsinoma invasif. Tipe ini memiliki cakupan morfologi yang bervariasi begitu juga perilaku klinis.…”

“…26 Kondisi ini berbeda dengan RS Arifin Achmad, RSUP M.Djamil dan RSCM dimana terbanyak adalah grade 2 dan RSUP Sarjito yang terbanyak adalah grade 3. 12,27,28 Frekuensi tipe molekuler pasien kanker payudara di RS Madiun terbanyak adalah luminal B, diikuti TN, luminal A dan HER2 sama banyak. Tipe Luminal B terbanyak juga ditemukan di RS Arifin Ahmad Pekanbaru dan RSCM Jakarta.…”

“…Tipe Luminal B terbanyak juga ditemukan di RS Arifin Ahmad Pekanbaru dan RSCM Jakarta. 12,24 Namun, tipe luminal A secara umum di dunia merupakan yang terbanyak. 29 Di Indonesia, tipe luminal A terbanyak ditemukan di RS Sarjito Yogyakarta, RS Hasan Sadikin Bandung, dan RS Adam Malik Medan.…”