Kardiovaskuläre Manifestationen bei Rheumatoider Arthritis

Moritz, F.; Wagner, Ulf; Distler, Oliver; Seidel, W.; Häntzschel, H

doi:10.1007/s00393-005-0732-6

Cited by 3 publications

(1 citation statement)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The risk of CVD in RA is believed to be due to a combination of traditional cardiovascular risk factors, such as hypertension, hyperlipidemia, and smoking, as well as RA-specific factors, such as inflammation and disease activity. RA patients may also develop pericarditis, myocarditis, and valvular disease [ 152 ].…”

Section: Cardiopathy In Rheumatoid Arthritismentioning

confidence: 99%

Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice

et al. 2023

View full text Add to dashboard Cite

Autoimmune heart disease is a non-random condition characterised by immune system-mediated aggression against cardiac tissue. Cardiac changes often exhibit nonspecific features and, if unrecognised, can result in fatal outcomes even among seemingly healthy young individuals. In the absence of reliable medical history, the primary challenge lies in differentiating between the various cardiopathies. Numerous immunohistochemical and genetic studies have endeavoured to characterise distinct types of cardiopathies, facilitating their differentiation during autopsy examinations. However, the presence of a standardised protocol that forensic pathologists can employ to guide their investigations would be beneficial. Hence, this summary aims to present the spectrum of autoimmune cardiopathies, including emerging insights such as SARS-CoV-2-induced cardiopathies, and proposes the utilisation of practical tools, such as blood markers, to aid forensic pathologists in their routine practice.

show abstract

Section: Cardiopathy In Rheumatoid Arthritismentioning

confidence: 99%

Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice

et al. 2023

View full text Add to dashboard Cite

show abstract

Rheumatoide Arthritis und kardiovaskuläre Komplikationen

et al. 2006

Self Cite

View full text Add to dashboard Cite

show abstract

Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells

2013

View full text Add to dashboard Cite

Shiga toxins are a family of genetically and structurally related toxins that are the primary virulence factors produced by the bacterial pathogens Shigella dysenteriae serotype 1 and certain Escherichia coli strains. The toxins are multifunctional proteins inducing protein biosynthesis inhibition, ribotoxic and ER stress responses, apoptosis, autophagy, and inflammatory cytokine and chemokine production. The regulated induction of inflammatory responses is key to minimizing damage upon injury or pathogen-mediated infections, requiring the concerted activation of multiple signaling pathways to control cytokine/chemokine expression. Activation of host cell signaling cascades is essential for Shiga toxin-mediated proinflammatory responses and the contribution of the toxins to virulence. Many studies have been reported defining the inflammatory response to Shiga toxins in vivo and in vitro, including production and secretion of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), macrophage inflammatory protein-1α/β (MIP-1α/β), macrophage chemoattractant monocyte chemoattractant protein 1 (MCP-1), interleukin 8 (IL-8), interleukin 6 (IL-6), and Groβ. These cytokines and chemokines may contribute to damage in the colon and development of life threatening conditions such as acute renal failure (hemolytic uremic syndrome) and neurological abnormalities. In this review, we summarize recent findings in Shiga toxin-mediated inflammatory responses by different types of cells in vitro and in animal models. Signaling pathways involved in the inflammatory responses are briefly reviewed.

show abstract

Kardiovaskuläre Manifestationen bei Rheumatoider Arthritis

Cited by 3 publications

References 71 publications

Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice

Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice

Rheumatoide Arthritis und kardiovaskuläre Komplikationen

Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells

Contact Info

Product

Resources

About