Kardiovaskulinės Sistemos Biologinis Laikrodis: Koks Cirkadinių Ritmų Vaidmuo Ūminio Miokardo Infarkto Patogenezėje?

Abstract

Aim of study: to analyse data of initial or re-hospitalizations in Vilnius University Hospital Santariskes Clinic Cardiologic Reanimation and Intensive Care unit due to acute myocardial infarction during the period from 2000 to 2010 year in order to identify, whether the desynchronization of circadian rhythms contributes toward acute myocardial infarction pathogenesis. Materials and methods: the study comprised clinical cases of 15333 patients. Median age was 66 ± 1,5 years. The inclusion criteria were: hospitalization in Vilnius University Hospital Cardiologic Reanimation and Intensive Care unit with diagnosis of the acute myocardial infarction during the period from 2000 – 01 – 01 to 2010 – 12 – 31. There were estimated 11 – years period total hospitalization rate at different four time intervals: 00:00 - 05:59 h; 06:00 - 11:59 h; 12:00 - 17:59 h; 18:00 - 23:59 h. Results: the annual tendency dominated in female‘s and male‘s with acute myocardial infarction – about 3,2 times more patients hospitalized from 06:00 h till 17:59 h, compared to 18:00 - 05:59 h interval data. Conclusions: the acute myocardial infarction pathogenesis mechanism is influenced by the diurnal variantions of the darkness – light phase, with increased risk of this pathology during the 06:00 – 17:59 h period.