Karyoplasmic Studies in Haploid, Androgenetic Hybrids of California Newts

Brandom, W.

doi:10.2307/1539272

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Polyploid amphibians have fewer large cells (Fankhauser, 1941;Jacobson and Hirose, 1978) than diploids and haploid animals have more small cells (Bradom, 1962). Chimeric animals have fewer large triploid cells opposite diploid cells in the same spinal cord (Sperry, 1991).…”

Section: Changes In Cell Numbermentioning

confidence: 99%

Reduction in cell size during development of the spinal cord

1999

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During development, spinal cord cells of the frog Xenopus laevis undergo a reduction in size. This phenomenon occurs during neural tube formation and continues at least until the start of metamorphosis. The number and shape of spinal cord cells also changes, but not always in synchrony with the reduction in cell size. The concomitant change in size and number of spinal cord cells during embryogenesis suggests that a cleavage type of reductive division contributes to the decrease in cell size. Blocking cell division with a combination of hydroxyurea and aphidicolin (HUA) stops the decrease in cell size during embryonic development without affecting the differentiation of a specific class of catecholaminergic neurons. HUA treatment during larval stages does not block the decrease in catecholaminergic neuron size. Thus, both mitotic and postmitotic cells decrease in size during spinal cord development. The two mechanisms are prevalent at different developmental stages with reductive division and cellular atrophy common during embryonic and larval phases, respectively. Like other regressive changes such as cell death and synapse elimination, decreases in cell size affect spinal cord morphogenesis and presumably the function of developing spinal cord cells. J. Comp. Neurol. 409:592–602, 1999. © 1999 Wiley‐Liss, Inc.

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Section: Changes In Cell Numbermentioning

confidence: 99%

Reduction in cell size during development of the spinal cord

1999

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“…Cell number is partially dependent on cell size. Polyploid amphibians have fewer large cells (Fankhauser, 1941;Jacobson and Hirose, 1978) than diploids and haploid animals have more small cells (Bradom, 1962). Chimeric animals have fewer large triploid cells opposite diploid cells in the same spinal cord (Sperry, 1991).…”

Section: Changes In Cell Numbermentioning

confidence: 99%

Reduction in cell size during development of the spinal cord

Chen¹,

Ekman²,

Heathcote³

1999

J. Comp. Neurol.

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During development, spinal cord cells of the frog Xenopus laeuis undergo a reduction in size. This phenomenon occurs during neural tube formation and continues at least until the start of metamorphosis. The number and shape of spinal cord cells also changes, but not always in synchrony with the reduction in cell size. The concomitant change in size and number of spinal cord cells during embryogenesis suggests that a cleavage type of reductive division contributes to the decrease in cell size. Blocking cell division with a combination of hydroxyurea and aphidicolin (HUA) stops the decrease in cell size during embryonic development without affecting the differentiation of a specific class of catecholaminergic neurons. HUA treatment during larval stages does not block the decrease in catecholaminergic neuron size. Thus, both mitotic and postmitotic cells decrease in size during spinal cord development. The two mechanisms are prevalent at different developmental stages with reductive division and cellular atrophy common during embryonic and larval phases, respectively. Like other regressive changes such as cell death and synapse elimination, decreases in cell size affect spinal cord morphogenesis and presumably the function of developing spinal cord cells.

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Nucleocytoplasmic Interactions in Development of Amphibian Hybrids

Subtelny

1974

International Review of Cytology

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Karyoplasmic Studies in Haploid, Androgenetic Hybrids of California Newts

Cited by 5 publications

References 6 publications

Reduction in cell size during development of the spinal cord

Reduction in cell size during development of the spinal cord

Reduction in cell size during development of the spinal cord

Nucleocytoplasmic Interactions in Development of Amphibian Hybrids

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