Kashin-Beck Disease: Current Status

Sokoloff, Leon

doi:10.1111/j.1753-4887.1988.tb05395.x

Cited by 29 publications

(12 citation statements)

References 10 publications

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“…The onset of KBD commonly occurs in preadolescent and adolescent years, and leads to various types of disabilities in adult life 15 . According to the China statistical yearbook of health and family planning in 2015, there were 0.61 million patients with KBD, of which 13,453 children were under 13 years of age in 378 counties of China 16 .…”

Section: Introductionmentioning

confidence: 99%

Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes

Yang

Zhao

et al. 2017

Sci Rep

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The relationship between T-2 toxin and deoxynivalenol (DON) and the risk of Kashin-Beck disease is still controversial since it is poorly known about their selectivity in cartilage damage. We aimed to compare the cytotoxicity of T-2 toxin and DON on cell lines representative of cell types encountered in vivo, including human chondrocytes (C28/I2), human hepatic epithelial cells (L-02) and human tubular epithelial cells (HK-2). In addition, we determined the distribution of T-2 toxin and DON in Sprague-Dawley (SD) rats after a single dose exposure. T-2 toxin or DON decreased proliferation in a time- and concentration-dependent manner and their combination showed a similar antagonistic effect in C28/I2, L-02 and HK-2 cells. Moreover, we observed cell cycle arrest and apoptosis, associated with increased oxidative stress and decline in mitochondrial membrane potential induced by T-2 toxin and/or DON. In vivo study showed that T-2 toxin and DON did not accumulate preferentially in the knee joint compared to liver and kidney after an acute exposure in SD rats. These results suggest that T-2 toxin and/or DON inhibit proliferation and induce apoptosis through a possible mechanism involving reactive oxygen species-mediated mitochondrial pathway that is not specific for chondrocytes in vitro or joint tissues in vivo.

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Section: Introductionmentioning

confidence: 99%

Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes

Yang

Zhao

et al. 2017

Sci Rep

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“…KBD is endemic in areas which extend from the North-East to the South-West of China (Sokoloff 1988; Hinsenkamp 2001). There are 0.65 million KBD patients in 378 KBD endemic counties having a total population of 38.07 million (National Health and Family Planning Commission of People’s Republic of China National Health and Family Planning Commission of People’s Republic of China 2014).…”

Section: Introductionmentioning

confidence: 99%

Reliability and validity of the EQ-5D-3L for Kashin–Beck disease in China

et al. 2016

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BackgroundKashin–Beck Disease (KBD) is an endemic osteoarthropathy in areas which extend from the North-East to the South-West of China. Most of the patients with KBD suffer multiple dysfunctions in major joints causing decreased health status. However because of their low education level and unique living habits, it is hard to find tools to measure the health-related quality of life (HRQOL). European quality of life (EQ-5D-3L) patient-reported instrument is widely used to measure HRQOL. This study aimed to establish the validity and reliability of the Chinese version of the EQ-5D-3L for evaluating HRQOL of KBD individuals in rural area.Methods368 individuals who were suffering from KBD were recruited through stratified multistage random sampling from Shaanxi province, China. The EQ-5D-3L and the WHOQOL-BREF were administrated in each individual by face to face interview. Test–retest reliability was assessed at 10–14 days intervals. The test–retest reliability was measured by calculating the Kappa coefficients for EQ-5D-3L five dimensions. For the EQ VAS, the intraclass correlation coefficient (ICC) was computed. Convergent and divergent analysis, construct validity was established using Spearman’s rank correlation between the EQ-5D-3L and the WHOQOL-BREF. Known groups’ validity was examined by comparing groups with a priori expected differences in health-related quality of life (HRQOL).ResultsFor 362 individuals (98%), comprehensive data of all the EQ-5D-3L dimensions were available. Kappa values of the EQ-5D-3L five items ranged from 0.324 to 0.554. ICC of the EQ VAS was 0.497. For convergent validity, the three items (self-care, usual activity, and mobility) of EQ-5D-3L, index scores, and VAS showed moderate correlations with the physical health domain of the WHOQOL-BREF (r absolute value ranged from 0.339 to 0.475). For divergent validity, the 5 items of EQ-5D-3L showed weak or no correlations with environment and social relationship domains of WHOQOL-BREF. The Chinese EQ-5D-3L clearly demarcated between groups which were reporting severe disease degree, poorer general health, more number of painful joints with worse HRQOL.ConclusionsThe EQ-5D-3L Chinese Version demonstrated fair to moderate levels of test–retest reliability and adequate construct validity in KBD individuals in China.

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“…Kashin-Beck disease (KBD) is a chronic, endemic, degenerative osteoarthropathy with severe skeletal deformation and dwarfism 1e3 . It is endemic to certain areas of South-Eastern Siberia to North China, North Korea, Central China and Tibet 4,5 . A report published by the Chinese Ministry of Health in 2008 estimated a population of 105.28 million people living in 366 counties within the KBD regions, and approximately 714.8 thousands of those people were found to be affected with KBD.…”

Section: Introductionmentioning

confidence: 99%