In the present paper, rst, we investigate a generalized Pochhammer's symbol and its various properties in terms of a new symbol (s, k), where s, k > 0. Then, we dene a generalization of gamma and beta functions and their various associated properties in the form of (s, k). Also, we dene new generalization of hypergeometric functions and develop dierential equations for generalized hypergeometric functions in the form of (s, k). We present that generalized hypergeometric functions are the solution of the said dierential equation. Furthermore, some useful results, properties and integral representation related to these generalized Pochhammer's symbol, gamma function, beta function, and hypergeometric functions are presented.