Kazachstania slooffiae: An unexpected journey to a human pleural sample

Mercier, Victor; Desnos‐Ollivier, Marie; Lamy, Anaïs; Mahul, Martin; Sasso, Milène

doi:10.1016/j.mycmed.2020.101109

Cited by 7 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most patients had an underlying condition that might have favored the infection, including a gastroesophageal pathologic condition in 4 of the 13 patients in our study, similar to the cases reported by Brunet et al and Mercier et al, suggesting a possible portal of entry ( 6 , 9 ). Moreover, 2 patients with IFI in our study reported exposure to pigeons; for 1 patient, we also isolated K. bovina from the pigeon droppings.…”

Section: Discussionsupporting

confidence: 89%

“…Among the K. telluris species complex, host specificity for K. bovina seems to be low because it has been isolated only from pigeons, a cow, and humans ( 4 , 5 ). To date, only 2 cases of invasive human infection caused by K. telluris complex have been described ( 6 , 9 ). One case was a K. bovina bloodstream infection, and the other was mediastinis caused by K. slooffiae.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fungal Infections Caused by Kazachstania spp., Strasbourg, France, 2007–2020

Kaeuffer¹,

Baldacini²,

Ruge³

et al. 2022

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Fungal Infections Caused by Kazachstania spp., Strasbourg, France, 2007–2020

Kaeuffer¹,

Baldacini²,

Ruge³

et al. 2022

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…Moreover, piglets are coprophagic and can consume, on average, 20 g of fecal material a day, including from the sow ( 67 ). K. slooffiae is not commonly found in environments outside the digestive systems of large mammals ( 56 , 68 , 69 ). Therefore, the sow is the most likely source of transmission to piglets and is a strong indicator of the piglet mycobiome ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Weaning transition, but not the administration of probiotic candidate Kazachstania slooffiae, shaped the gastrointestinal bacterial and fungal communities in nursery piglets

Harlow,

Summers,

Oliver

et al. 2024

Front. Vet. Sci.

View full text Add to dashboard Cite

As in-feed antibiotics are phased out of swine production, producers are seeking alternatives to facilitate improvements in growth typically seen from this previously common feed additive. Kazachstania slooffiae is a prominent commensal fungus in the swine gut that peaks in relative abundance shortly after weaning and has beneficial interactions with other bacteriome members important for piglet health. In this study, piglets were supplemented with K. slooffiae to characterize responses in piglet health as well as fungal and bacterial components of the microbiome both spatially (along the entire gastrointestinal tract and feces) and temporally (before, during, and after weaning). Litters were assigned to one of four treatments: no K. slooffiae (CONT); one dose of K. slooffiae 7 days before weaning (day 14; PRE); one dose of K. slooffiae at weaning (day 21; POST); or one dose of K. slooffiae 7 days before weaning and one dose at weaning (PREPOST). The bacteriome and mycobiome were analyzed from fecal samples collected from all piglets at day 14, day 21, and day 49, and from organ samples along the gastrointestinal (GI) tract at day 21 and day 49. Blood samples were taken at day 14 and day 49 for cytokine analysis, and fecal samples were assayed for antimicrobial resistance. While some regional shifts were seen in response to K. slooffiae administration in the mycobiome of the GI tract, no remarkable changes in weight gain or health of the animals were observed, and changes were more likely due to sow and the environment. Ultimately, the combined microbiome changed most considerably following the transition from suckling to nursery diets. This work describes the mycobiome along the piglet GI tract through the weaning transition for the first time. Based on these findings, K. slooffiae administered at this concentration may not be an effective tool to hasten colonization of K. slooffiae in the piglet GI tract around the weaning transition nor support piglet growth, microbial gut health, or immunity. However, diet and environment greatly influence microbial community development.

show abstract

“…K. slooffiae was isolated in the pleural sample, and sensibility testing could not be performed. The patient was treated with caspofungin for six weeks showing good recovery [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Kazachstania slooffiae, an emerging pathogen to watch for in humans?

Gallotti,

Lombera,

Pinto

et al. 2023

Medical Mycology Case Reports

View full text Add to dashboard Cite

Kazachstania slooffiae: An unexpected journey to a human pleural sample

Cited by 7 publications

References 14 publications

Fungal Infections Caused by Kazachstania spp., Strasbourg, France, 2007–2020

Fungal Infections Caused by Kazachstania spp., Strasbourg, France, 2007–2020

Weaning transition, but not the administration of probiotic candidate Kazachstania slooffiae, shaped the gastrointestinal bacterial and fungal communities in nursery piglets

Kazachstania slooffiae, an emerging pathogen to watch for in humans?

Contact Info

Product

Resources

About