Kazakh strains of tobacco mosaic virus: two strains with potentially destabilizing amino acid substitutions in the coat protein

Novikov, V. K.; Belenovich, E. V.; Добров, Е. Н.; Завриев, С. К.

doi:10.1006/pmpp.1999.0251

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…The host ranges of different TMV isolates collected from different hosts and regions were similar to what has been previously reported for TMV ( Chung et al, 2007 ; Jung et al, 2002 ; Novikov et al, 2000 ), but considerable differences were found in the symptoms induced by each TMV isolate on the indicator plants. The five TMV pathology clusters studied in this research showed obvious differences in the symptom development on C. quinoa , cowpea cv.…”

Section: Discussionsupporting

confidence: 81%

Prevalence of Tobacco mosaic virus in Iran and Evolutionary Analyses of the Coat Protein Gene

Alishiri

Rakhshandehroo

Zamanizadeh

et al. 2013

The Plant Pathology Journal

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The incidence and distribution of Tobacco mosaic virus (TMV) and related tobamoviruses was determined using an enzyme-linked immunosorbent assay on 1,926 symptomatic horticultural crops and 107 asymptomatic weed samples collected from 78 highly infected fields in the major horticultural crop-producing areas in 17 provinces throughout Iran. The results were confirmed by host range studies and reverse transcription-polymerase chain reaction. The overall incidence of infection by these viruses in symptomatic plants was 11.3%. The coat protein (CP) gene sequences of a number of isolates were determined and disclosed to be a high identity (up to 100%) among the Iranian isolates. Phylogenetic analysis of all known TMV CP genes showed three clades on the basis of nucleotide sequences with all Iranian isolates distinctly clustered in clade II. Analysis using the complete CP amino acid sequence showed one clade with two subgroups, IA and IB, with Iranian isolates in both subgroups. The nucleotide diversity within each sub-group was very low, but higher between the two clades. No correlation was found between genetic distance and geographical origin or host species of isolation. Statistical analyses suggested a negative selection and demonstrated the occurrence of gene flow from the isolates in other clades to the Iranian population.

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Section: Discussionsupporting

confidence: 81%

Prevalence of Tobacco mosaic virus in Iran and Evolutionary Analyses of the Coat Protein Gene

Alishiri

Rakhshandehroo

Zamanizadeh

et al. 2013

The Plant Pathology Journal

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“…TMV CP is characterized as a well-ordered dimer of a bilayered cylindrical disk, formed by 34 chemically identical subunits assembled around a single strand of viral RNA [58] (Figure 1). CPs show interesting biological functions, playing a key role in the encapsulation and protection of single strand RNA virus genome [56,61,62], and being involved in the symptom modulation [63][64][65]. CPs are involved in the CP mediated resistance (CP-MR), a phenomenon in which mutant also reduced the formation of virus replication complexes [66,67].…”

Section: Introductionmentioning

confidence: 99%

“…CPs show interesting biological functions, playing a key role in the encapsulation and protection of single strand RNA virus genome [ 56 , 61 , 62 ], and being involved in the symptom modulation [ 63 , 64 , 65 ]. CPs are involved in the CP mediated resistance (CP-MR), a phenomenon in which mutant also reduced the formation of virus replication complexes [ 66 , 67 ].…”

Section: Introductionmentioning

confidence: 99%

Autoxidation Products of the Methanolic Extract of the Leaves of Combretum micranthum Exert Antiviral Activity against Tomato Brown Rugose Fruit Virus (ToBRFV)

Iobbi

Lanteri²,

Minuto³

et al. 2022

Molecules

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Tomato brown rugose fruit virus (ToBRFV) is a new damaging plant virus of great interest from both an economical and research point of view. ToBRFV is transmitted by contact, remains infective for months, and to-date, no resistant cultivars have been developed. Due to the relevance of this virus, new effective, sustainable, and operator-safe antiviral agents are needed. Thus, 4-hydroxybenzoic acid was identified as the main product of the alkaline autoxidation at high temperature of the methanolic extract of the leaves of C. micranthum, known for antiviral activity. The autoxidized extract and 4-hydroxybenzoic acid were assayed in in vitro experiments, in combination with a mechanical inoculation test of tomato plants. Catechinic acid, a common product of rearrangement of catechins in hot alkaline solution, was also tested. Degradation of the viral particles, evidenced by the absence of detectable ToBRFV RNA and the loss of virus infectivity, as a possible consequence of disassembly of the virus coat protein (CP), were shown. Homology modeling was then applied to prepare the protein model of ToBRFV CP, and its structure was optimized. Molecular docking simulation showed the interactions of the two compounds, with the amino acid residues responsible for CP-CP interactions. Catechinic acid showed the best binding energy value in comparison with ribavirin, an anti-tobamovirus agent.

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“…En el TCV se ha observado que varios mutantes en la zona que conecta los dominios S y P de su CP causan síntomas más graves que la infección con la cepa silvestre (Lin and Heaton, 1999). También se ha demostrado que la CP de otros virus incluyendo tobamovirus (Dawson, 1992;Novikov et al, 2000), luteovirus (Bencharki et al, 2000) y cucumovirus (Zhang et al, 1994;Sugiyama et al, 2000) están relacionadas con la modulación de los síntomas.…”

Section: Sintomatologíaunclassified

Relación estructura-función de las proteínas virales implicadas en el movimiento de los carmovirus y su interacción con factores celulares

Soriano¹

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Kazakh strains of tobacco mosaic virus: two strains with potentially destabilizing amino acid substitutions in the coat protein

Cited by 6 publications

References 25 publications

Prevalence of Tobacco mosaic virus in Iran and Evolutionary Analyses of the Coat Protein Gene

Prevalence of Tobacco mosaic virus in Iran and Evolutionary Analyses of the Coat Protein Gene

Autoxidation Products of the Methanolic Extract of the Leaves of Combretum micranthum Exert Antiviral Activity against Tomato Brown Rugose Fruit Virus (ToBRFV)

Relación estructura-función de las proteínas virales implicadas en el movimiento de los carmovirus y su interacción con factores celulares

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