Insecticides applications are one of the components to control brown planthoppers pest that are applied in large scale by farmers. In the field, some farmers mix different active ingredients of insecticides to control brown planthoppers. This study was aimed to find out the efficacy of mixed insecticides to brown plant hoppers and the effect on natural enemies in the field. The research was carried out in Pemalang Regency, Central Java, in 2016/2017 rice planting season. There were eleven treatments with three replications in 5x8 m2 plots using randomized completed block design. Two successive sprays of selected insecticides were applied with sprayer at 14 days interval. Insecticides Pymetrozine 480 + Imidacloprid 160 (150+50), Pymetrozine 480 + Imidacloprid 160 (75+25), Pymetrozine 185 + Buprofezin 240 (150+194,59), Pymetrozine 185 + Buprofezin 240 (75+97,3), and Buprofezin 240 + Fipronil 40 (100+16,67) effectively controlled the population of brown planthopper with the efficacy as follows 96.78%; 94.27%; 96.45%; 96.71%; and 94.01%. Insecticides mixtures tested did not affect the population of natural enemies such as spiders, Paederus, and C. lividipennis.