Keep cystic fibrosis patients out of the hospital

Dasenbrook, Elliot

doi:10.3949/ccjm.87a.ccc005

Cited by 6 publications

(8 citation statements)

References 8 publications

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“…Our care team worked out some creative solutions such as home spirometers for those with serious lung disease, subsequent check-in and training with respiratory therapy, options for mail-in or drop-off of sputum samples, and telemedicine and video visits. 6 This was in line with guidance provided by the leadership of the CF Foundation.…”

supporting

confidence: 65%

Cystic Fibrosis and COVID-19

Chapman

Moffett

2020

Southern Medical Journal

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supporting

confidence: 65%

Cystic Fibrosis and COVID-19

Chapman

Moffett

2020

Southern Medical Journal

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“…This may be only due to the fact that CF patients have always paid close attention to infection control and social distancing [ 18 ]. Moreover, at the very beginning of the pandemic, CF centers worldwide reorganized their classical care to “keep cystic fibrosis patients out of the hospital” as stated by Dasenbrook [ 19 ]. The North-American and European recommendations were as follows: (i) to start CFTR modulators as soon as possible, to reduce pulmonary exacerbations and hospitalizations; (ii) to practice telemedicine as much as possible; (iii) to reinforce adherence to already prescribed regimens; (iv) to promptly and aggressively treat CF exacerbations to prevent avoidable hospitalizations; and (v) to continue to communicate with the patients by emails, phone calls, etc.…”

Section: Discussionmentioning

confidence: 99%

“…The North-American and European recommendations were as follows: (i) to start CFTR modulators as soon as possible, to reduce pulmonary exacerbations and hospitalizations; (ii) to practice telemedicine as much as possible; (iii) to reinforce adherence to already prescribed regimens; (iv) to promptly and aggressively treat CF exacerbations to prevent avoidable hospitalizations; and (v) to continue to communicate with the patients by emails, phone calls, etc. [ 18 , 19 ]. These measures were applied by the CF centers worldwide and seem to have been beneficial for patients with CF.…”

Section: Discussionmentioning

confidence: 99%

First Wave of COVID-19 in French Patients with Cystic Fibrosis

Corvol

Miranda

Lemonnier

et al. 2020

JCM

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Viral infections are known to lead to serious respiratory complications in cystic fibrosis (CF) patients. Hypothesizing that CF patients were a population at high risk for severe respiratory complications from SARS-CoV-2 infection, we conducted a national study to describe the clinical expression of COVID-19 in French CF patients. This prospective observational study involves all 47 French CF centers caring for approximately 7500 CF patients. Between March 1st and June 30th 2020, 31 patients were diagnosed with COVID-19: 19 had positive SARS-CoV-2 RT-PCR in nasopharyngeal swabs; 1 had negative RT-PCR but typical COVID-19 signs on a CT scan; and 11 had positive SARS-CoV-2 serology. Fifteen were males, median (range) age was 31 (9–60) years, and 12 patients were living with a lung transplant. The majority of the patients had CF-related diabetes (n = 19, 61.3%), and a mild lung disease (n = 19, 65%, with percent-predicted forced expiratory volume in 1 s (ppFEV1) > 70). Three (10%) patients remained asymptomatic. For the 28 (90%) patients who displayed symptoms, most common symptoms at admission were fever (n = 22, 78.6%), fatigue (n = 14, 50%), and increased cough (n = 14, 50%). Nineteen were hospitalized (including 11 out of the 12 post-lung transplant patients), seven required oxygen therapy, and four (3 post-lung transplant patients) were admitted to an Intensive Care Unit (ICU). Ten developed complications (including acute respiratory distress syndrome in two post-lung transplant patients), but all recovered and were discharged home without noticeable short-term sequelae. Overall, French CF patients were rarely diagnosed with COVID-19. Further research should establish whether they were not infected or remained asymptomatic upon infection. In diagnosed cases, the short-term evolution was favorable with rare acute respiratory distress syndrome and no death. Post-lung transplant patients had more severe outcomes and should be monitored more closely.

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“…Patients and parents with CLD are more likely to practice careful protective behaviors in order to avoid respiratory infections; these behaviors include hand hygiene, mask wearing, and social distancing [ 16 ]. This conduct has been reinforced during the first wave of COVID-19 by North-American and European recommendations, which advised to prevent pulmonary exacerbations [ 16 , 17 , 18 ].…”

Section: How Cld Could Affect the Risk Of Sars-cov-2 Infectionmentioning

confidence: 99%

Impact of COVID-19 in Children with Chronic Lung Diseases

Ferraro

Zanconato

Carraro

2022

IJERPH

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Background: since December 2019, the world has become victim of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The aim of our narrative review is to analyze the impact of COVID-19 in children suffering from chronic lung disease (CLD). Methods: we searched the MEDLINE/Pubmed database using the terms “SARS-CoV-2” or “COVID-19” or “Coronavirus Diseases 2019”; AND “chronic lung diseases” or “chronic respiratory diseases” or “asthma” or “cystic fibrosis” or “primary ciliary dyskinesia” or “bronchopulmonary dysplasia”; and limiting the search to the age range 0–18 years. Results and Conclusions: although COVID-19 rarely presents with a severe course in children, CLD may represent a risk factor; especially when already severe or poorly controlled before SARS-CoV-2 infection. On the other hand, typical features of children with CLD (e.g., the accurate adoption of prevention measures, and, in asthmatic patients, the regular use of inhaled corticosteroids and T2 inflammation) might have a role in preventing SARS-CoV-2 infection. Moreover, from a psychological standpoint, the restrictions associated with the pandemic had a profound impact on children and adolescents with CLD.

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Keep cystic fibrosis patients out of the hospital

Cited by 6 publications

References 8 publications

Cystic Fibrosis and COVID-19

Cystic Fibrosis and COVID-19

First Wave of COVID-19 in French Patients with Cystic Fibrosis

Impact of COVID-19 in Children with Chronic Lung Diseases

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