Kelainan Kardiovaskular pada Anak dengan Berbagai Stadium Penyakit Ginjal Kronik

Abstract

Latar belakang. Penyakit kardiovaskular (PKV) merupakan penyebab morbiditas dan mortalitas tersering pada penyakit ginjal kronik (PGK) anak. Hipertrofi ventrikel kiri (LVH) dan disfungsi diastolik paling awal terlihat. Tujuan. Mengetahui proporsi PKV pada PGK stadium 1, hubungan stadium PGK dengan LVH, dan disfungsi jantung. ). Uji stastistik bermakna bila p<0,05. Hasil. Rerata umur subjek 9,1(3,8) tahun. LVH pada 1 dari 3 subjek PGK stadium 1 dan 61,5% pada PGK seluruh stadium, terbanyak stadium 5. Tidak terdapat hubungan bermakna stadium PGK dengan LVH (p=0,055), disfungsi diastolik (p=0,937) dan disfungsi sistolik (p=0,929). Kesimpulan. Pada PGK stadium 1 ditemukan LVH dan disfungsi diastolik. Tidak terdapat hubungan antara stadium PGK dengan LVH dan disfungsi jantung. Sari Pediatri 2016;18(3):220-5Kata kunci: PGK anak, kelainan kardiovaskular Cardiovascular Disorders in Children with Various Stages of Chronic Kidney DiseaseAumas Pabuti,* Nanan Sekarwana,* Partini P. Trihono** Background. Cardiovascular disorders (CVD) are common cause of morbidity and mortality in chronic kidney disease (CKD)'s children. Left ventricle hypertrophy (LVH) and diastolic dysfunction are early sign. Objectives. To study are knowing CVD in CKD stage I, association stages of CVD with LVH, and cardiac dysfunction. Methods. Cross sectional study 26 children with CKD in M Djamil Hospital/ Hasan Sadikin Hospital. Electrocardiography, chest X-ray, echocardiography was measured. LVH if left ventriculer mass index (LVMI) is >95th percentile (38 g/h

Calcitriol levels and the stage of chronic kidney disease in children

“…Pabuti et al found that 50% of the pediatric CKD subjects in his study were in stage V. The large proportion of advanced stage CKD may have been due to lack of public awareness, such that patients usually consulted a physician late, or lack of competence among healthcare workers in the early detection of CKD in children. 4 Slightly more than half of subjects had failure to thrive (51.2%), indicating that chronic nutritional disorders are common in children with CKD. Failure to thrive in children with CKD may be caused by several factors, including malnutrition, dehydration, hyponatremia, metabolic acidosis, uremia, anemia, renal osteodystrophy, and growth hormone resistance.…”

“…These changes cause suppression of 1α-hydroxylase enzyme activity, which prevents the conversion of vitamin D into the active form 1,25(OH) 2 D 3 (calcitriol). 3 Most cases of pediatric CKD in Indonesia are detected at an advanced stage, 4 including those in West Sumatra and its surroundings who seek treatment at Dr. M. Djamil Hospital, Padang, West Sumatera. In addition, due to sociocultural factors, most children wear school uniforms that cover most of their body, reducing sun exposure and leading to decreased vitamin D and increasing the risk of CKD-MBD as CKD complications.…”