The study of nanofluids has become a key research area in mathematics, physics, engineering, and materials science. Nowadays, nanofluids are widely used in many industrial applications to improve thermophysical properties such as thermal conductivity, thermal diffusivity, convective heat transfer, and viscosity. This article discusses the effects of heat generation/absorption and chemical reaction on magnetohydrodynamics (MHD) flow of Williamson nanofluid over an inclined stretching surface. The impact of Williamson factor on velocity field is investigated numerically using Keller box analysis (KBA). Suitable similarity transformations are used to recover ordinary differential equations (ODEs) from the boundary flow equations. These ordinary differential equations are addressed numerically. The numerical computations revealed that energy and species exchange decrease with rising values of magnetic field. Moreover, it is found that increasing the chemical reaction parameter increases the Nusselt number and decreases skin friction. Further, the effect of Lewis parameter diminishes energy transport rate. In the same vein, it is also observed that increasing the inclination can enhance skin friction, while the opposite occurred for the energy and species transport rate. As given numerical computations demonstrate, our results are in reasonable agreement with the reported earlier studies.