2002
DOI: 10.1007/s00105-001-0316-6
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Keloide Eine dermale fibroproliferative Erkrankung unbekannter Ursache

Abstract: We review recent advances in keloid research and treatment. Keloids are benign tumours of the skin. They tend to occur in younger patients after different kinds of injuries, infections or they may develop spontaneously. In contrast to hypertrophic scars, keloids are not confined to the original wound, but grow into the corresponding healthy skin. They rarely recede within time. Most patients complain of itching and suffer from impairment of their quality of life. Only little is known about the pathogenesis of … Show more

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Cited by 22 publications
(11 citation statements)
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References 45 publications
(48 reference statements)
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“…An inactive keloid shows cessation of scar growth but no degeneration of the elevated tissue (4,11,30). Furthermore, the resulting disfigurement not only leads to a cosmetic nuisance, but often results in a significant burden for the patient (8,9,37,38).…”
Section: Keloids Versus Hypertrophic Scarsmentioning
confidence: 99%
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“…An inactive keloid shows cessation of scar growth but no degeneration of the elevated tissue (4,11,30). Furthermore, the resulting disfigurement not only leads to a cosmetic nuisance, but often results in a significant burden for the patient (8,9,37,38).…”
Section: Keloids Versus Hypertrophic Scarsmentioning
confidence: 99%
“…Both types of scars show increased deposition of collagen and proteoglycans within the dermis and the subcutis. A common characteristic is the increased fibroblast density, but only keloids have increased fibroblast proliferation rates (8,37). The collagen bundles in the dermis of normal mature scar tissue appear relaxed and in an unordered arrangement.…”
Section: Keloids Versus Hypertrophic Scarsmentioning
confidence: 99%
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“…Da die Pathogenese der keloidalen Narben bis heute weitgehend unklar ist [3], kann auch über den detaillierten Ablauf eines mög- …”
Section: Introductionunclassified
“…Die letztendliche Ursache dieser Regulationsstörung ist unbekannt, lokalisatorische und genetische Faktoren (familiäre Häufung, Bevorzugung Hauttyp 3 -6) scheinen aber wichtige Grundvoraussetzungen zu sein [3]. Eine Unterscheidung hypertropher Narben und Keloide erfolgt vor allen Dingen klinisch, da Keloide meist im Sinne eines benignen Tumors deutlich über die eigentlichen Narbenkonturen hinauswachsen und eher selten zu spontanen Involutionen neigen.…”
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