Keloids demonstrate high-level epidermal expression of vascular endothelial growth factor

Gira, Amy Kim; Brown, Lawrence F.; Washington, Carl V.; Cohen, Cynthia; Arbiser, Jack L.

doi:10.1016/j.jaad.2003.11.061

Cited by 96 publications

(90 citation statements)

References 33 publications

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“…68,69 High levels of VEGF have also been described in keloids in the skin. 70,71 Further studies will have to be conducted to assess potential clinical uses for VEGF neutralization in limiting scar formation or managing more severe fibrotic diseases.…”

Section: Discussionmentioning

confidence: 99%

Regulation of scar formation by vascular endothelial growth factor

Wilgus

Ferreira

Oberyszyn

et al. 2008

Laboratory Investigation

277

216

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Section: Discussionmentioning

confidence: 99%

Regulation of scar formation by vascular endothelial growth factor

Wilgus

Ferreira

Oberyszyn

et al. 2008

Laboratory Investigation

277

216

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“…28 Similarly, exogenous TGF -1 causes a greater increase in collagen synthesis in keloid-derived fibroblasts compared to fibroblasts derived from normal dermis . 30 Both Wu et al 31 and Gira et al 32 have shown increased levels of VEGF in keloids. Dupuytren's Contracture cord and wound granulation tissue have similar histological features, leading to the view that DD may be a dysregulated, fibrotic wound healing response.…”

Section: Discussionmentioning

confidence: 98%

“…20,21 Of the many cytokines involved, recent studies suggest that transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor (VEGF) may play key roles in atherosclerosis, including the formation of carotid atherosclerotic plaques. [22][23][24][25][26][27] It is interesting that these same cytokines have been implicated in the pathogenesis of abnormal cutaneous scarring [28][29][30][31][32][33][34] and suggested as components of Dupuytren's contracture. 35,36 Atherosclerosis, a response to injury 7,8 , includes a major component of scarring in the artery wall.…”

Section: Discussionmentioning

confidence: 99%

Keloid scarring, but not Dupuytren’s contracture, is associated with unexplained carotid atherosclerosis

Bhavsar

Nimigan²,

Hackam³

et al. 2009

CIM

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Background: Atherosclerosis, a response to injury, may be thought of as scarring in the artery wall. TGF-and associated signaling molecules have been implicated in the pathophysiology of keloid scarring, Dupuytren's Contracture and atherosclerotic plaques in independent studies. Purpose: To test the hypothesis that excess cutaneous scarring and Dupuytren's contractures predispose independently to carotid atherosclerosis . Methods: Among 1,747 patients with plaque measurements and complete data for multivariable regression analysis, 57 Caucasian patients had Dupuytren's contractures and 12 had keloid scars. Carotid total plaque area (TPA) was measured by 2-Dimensional ultrasound. Results: In linear multivariable regression analysis with coronary risk factors, keloid scars were associated with TPA (P= 0.018), but Dupuytren's contractures were not. Patients with keloid scarring were younger (P<0.0001), and more likely to be diabetic (P<0.0001) Conclusions: Keloid scarring is a clinical clue to excess atherosclerosis not explained by traditional risk factors. Such patients may benefit from therapy directed at targets related to signalling molecules common to both the process of keloid scarring and atherosclerosis. These findings suggest previously unexplored possibilities for the prevention and treatment of atherosclerosis. The differences between

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“…28 However, VEGF was found to be highly expressed in keloid tissues. 29 Moreover, Steinbrech found that hypoxia could stimulate upregulating of VEGF expression in KFs. 30 Interestingly, Ryoma Touchi's study showed that there is no significant difference in VEGF expression between central and marginal areas.…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%

The Characteristics of Blood Supply and Tissue Hypoxia in Pathological Scars

李梓菲¹,

Li²,

刘清亮³

et al. 2017

Chinese Medical Sciences Journal

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Blood supply is believed to be an important aspect in the development of pathological scars. However, there are controversies about vascular distribution, vascular structure and blood flow in pathological scars. Additionally, hypoxic microenvironment plays an important role in the vascularization of pathological scar tissues, and hypoxic conditions can be reflected by metabolic indexes and some cytokines. Furthermore, the correlation between blood supply and tissue hypoxia is controversial. The aim of this article is to review the literature on the characteristics of blood supply and tissue hypoxia in pathological scars, from which we can see pathological scars have unique characteristics of blood supply that are closely associated with tissue hypoxia. Moreover, development in the treatment of pathological scars is herein reviewed.Chin Med Sci J 2017; 32(2):113-118. DOI:10.24920/J1001-9294.2017.014 ATHOLOGICAL scars include hypertrophic scar and keloid. They influence appearance and even cause functional disturbance, and place tremendous physiological and psychological burdens on patients. Therefore, pathological scars have been a challenge in plastic surgery and the focus of research.Blood supply is believed to be an important aspect in the development of pathological scars, and has thus attracted more attentions in recent years. However, there are controversies about blood supply in pathological scars.Hereby we summarized the advances of research on the blood supply in pathological scars, and explored future research directions. The vascular structure of pathological scars has different manifestations between hypertrophic scars and keloids. In terms of spatial vascular structure, blood vessels within hypertrophic scar tissues have a structure perpendicular to the skin surface, whereas those within keloid tissues present a typical dispersed, extended vascular structure. VASCULARITY OF PATHOLOGICAL SCARS 5,6The diameter or patency of the blood vessels of pathological scar remains controversial. Thaís et al used stereological methods to obtain information on pathological scar tissues with a microscope, and proposed that the blood vessels within the pathological scars were dilated compared with those in normal skin and normal scars.

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Keloids demonstrate high-level epidermal expression of vascular endothelial growth factor

Cited by 96 publications

References 33 publications

Regulation of scar formation by vascular endothelial growth factor

Regulation of scar formation by vascular endothelial growth factor

Keloid scarring, but not Dupuytren’s contracture, is associated with unexplained carotid atherosclerosis

The Characteristics of Blood Supply and Tissue Hypoxia in Pathological Scars

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