2008
DOI: 10.1016/j.humpath.2007.11.017
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Keratin immunohistochemistry does not contribute to correct lymph node staging in patients with invasive lobular carcinoma

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Cited by 12 publications
(13 citation statements)
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References 33 publications
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“…In addition to the 2 possible reasons (see discussion in Patil and Susnik [1]) why there may be a discrepancy in the results between the multiinstitutional study by Cserni et al [2] and our study, the authors highlight 2 additional differences:…”
contrasting
confidence: 54%
See 1 more Smart Citation
“…In addition to the 2 possible reasons (see discussion in Patil and Susnik [1]) why there may be a discrepancy in the results between the multiinstitutional study by Cserni et al [2] and our study, the authors highlight 2 additional differences:…”
contrasting
confidence: 54%
“…Dr Cserni et al in their letter to the editor question the conclusion of our single-institution retrospective analysis of 76 cases of sentinel lymph node (SLN) excision from patients with invasive lobular carcinoma [1]. We read their comments with great interest and respectfully disagree with their interpretation of our study that cytokeratin immunohistochemistry (IHC) in SLN for invasive lobular carcinoma is "useless."…”
mentioning
confidence: 87%
“…In our series IHC was used to assess ALN of all lobular tumors when routine H&E was negative. While contribution of IHC over H&E to improve lymph nodal staging in ILC remains controversial [18,19], one could assume the possibility of a higher false negative rate in the non-ILC group since IHC was not performed in these cases. Therefore, we might even be underestimating differences in ALN involvement between ILC and non-ILC.…”
Section: Discussionmentioning
confidence: 99%
“…-The smaller mean tumor size in our series (mean of 2.0 versus 2.8 cm); and -A different interpretation of intraparenchymal multicellular nodal deposits less than 0.2 mm (micrometastasis according to the European Working Group for Breast Screening Pathology interpretation of the TNM categories [3,4] and isolated tumor cells, hence node-negative status in the analysis by Patil and Susnik [1] and others [4,5]). …”
Section: Immunohistochemistry To Detect Sentinel Nodal Metastases In mentioning
confidence: 60%
“…Patil and Susnik [1] report on the uselessness of cytokeratin immunohistochemistry (IHC) in the evaluation of sentinel lymph nodes (SLNs) of patients with invasive lobular carcinomas of the breast. Their study is based on the retrospective analysis of 76 cases, of which 24 were SLN positive, but only one of these metastatic cases (a micrometastasis) was discovered by IHC.…”
Section: Immunohistochemistry To Detect Sentinel Nodal Metastases In mentioning
confidence: 99%