Lobular and non-lobular breast cancers differ regarding axillary lymph node metastasis: a cross-sectional study on 4,292 consecutive patients

Vandorpe, Thijs; Smeets, Ann; Calster, Ben Van; Hoorde, Kirsten Van; Leunen, Karin; Amant, Frédéric; Moerman, Ph.; Deraedt, Karen; Brouckaert, Olivier; Huffel, Sabine Van; Wildiers, Hans; Christiaens, Melissa; Neven, Patrick

doi:10.1007/s10549-011-1565-4

Cited by 26 publications

(29 citation statements)

References 26 publications

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“…In terms of pathological types, the present study showed that the higher the histological grade was, the greater SLN metastasis patients had. This is also in consistent with the results of other studies 17, 18, 19. As for the ER status, our study shows that patients with positive ER were more likely to have SLN metastasis, and patients with positive ER were more likely to be PR positive and HER‐2 positive as well.…”

Section: Discussionsupporting

confidence: 93%

Feasibility of using negative ultrasonography results of axillary lymph nodes to predict sentinel lymph node metastasis in breast cancer patients

Chen

Wang

et al. 2018

Cancer Medicine

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Knowledge of the pathology of axillary lymph nodes (ALN) in breast cancer patients is critical for determining their treatment. Ultrasound is the best noninvasive evaluation for the ALN status. However, the correlation between negative ultrasound results and the sentinel lymph nodes (SLN) pathology remains unknown. To test the hypothesis that negative ultrasound results of ALN predict the negative pathology results of SLN in breast cancer patients, we assessed the association between ALN ultrasonography‐negative results and the SLN pathology in 3115 patients with breast cancer recruited between October 2010 and April 2016 from a single cancer center, prospective database. Of these patients who met the inclusion criteria, 2317 (74.4%) had no SLN pathological metastasis. In the univariate analysis, other 798 patient with positive SLN tended to be under age 40 and premenopausal, having large tumor sizes (>2 cm), higher histological grade of primary tumor, positive hormone receptors, and negative HER‐2 status (P < .05 for all). In the multivariate analysis, menstrual status, tumor size, ER status and histological types of primary tumor remained to be independent predictors for SLN pathological metastasis. The area under curve (AUC) was 0.658 (95% CI = 0.637‐0.679), P > .05. In conclusion, only a 74.4% consistency between ALN ultrasonography‐negative results and negative pathological SLN results, although menstrual status, tumor size, histologic subtypes of primary tumor and ER status were found to be statistically independent predictors of positive SLN among patients negative for ALN ultrasonography. Therefore, the present study suggests that negative ultrasound results of ALN do not adequately predict the negative pathology results of SLN in breast cancer patients.

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Section: Discussionsupporting

confidence: 93%

Feasibility of using negative ultrasonography results of axillary lymph nodes to predict sentinel lymph node metastasis in breast cancer patients

Chen

Wang

et al. 2018

Cancer Medicine

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“…The pN0 rates in our patients with newly diagnosed IDC were 52%, while it was 41% for those with ILC and IMC, similar to the literature (30). The pathological stage of cases in our study was also more advanced in ILC+IMC cases.…”

Section: Discussionsupporting

confidence: 88%

Breast Cancer in Turkey: Clinical and Histopathological Characteristics (Analysis of 13.240 Patients)

Özmen

2014

J Breasth Health

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Objective: Breast cancer is the most common type of cancer and the leading cause of cancer related deaths in women in Turkey, as elsewhere around the world. However, detailed and systematic demographics, data on clinical and pathological characteristics, and treatment were largely unavailable in Turkey until now. This paper is intended to provide an analysis of clinical and pathological data on women registered in the National Breast Cancer Database (Ulusal Meme Kanseri Veri Tabanı Results: A total of 13,240 patients with breast cancer since April 07, 1992 were included in the study, and 99% of them were female. Female breast cancer patients whose requisite parameters had been completely entered in the database were included in the analysis. The mean age was 51.6 years (±12.6; range 12-97), 17% of them were younger than 40 years of age, and 45% were premenopausal. According to an analysis of age groups at diagnosis, the frequency of cancer peaked at the 45 -49 age group with 16.7%, declining to 7.6% in the 65-69 age group, and then rose again. Most of the patients (78.7%) had invasive ductal, 7.8% were invasive lobular cancers, 9.8% were invasive mixed cancers (invasive ductal + invasive lobular), and 4% were other histological types (e.g. inflammatory, intracystic papillary, mucinous, etc.), respectively. Half of them (50%) had grade III histology. According to an analysis of pathological stages of all breast cancers (stage 0 -IV), 5% were stage 0, 27% were stage I, 44% were stage II, 21% were stage III, and 3% were stage IV breast cancer, respectively. The mean tumor diameter was 2.5 cm (±1.6; range 0.1-20 cm). The rates of lymphatic stages were pN0 50%, pN1 28%, pN2 15%, and pN3 7%, respectively. ER, PR, and HER-2 receptors were positive in 70%, 59%, and 23% of patients. A subtype analysis of tumors showed that 62% were type luminal A. This was followed by subtypes luminal B (15%), triple negative (15%), and HER-2 positive (8.5%). Conclusion:As a conclusion patients with breast cancer in our breast cancer registry program were younger, and had more advanced disease, and worse prognostic factors than patients in developed countries.

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“…Our study also showed that non-invasive ductal carcinomas were not associated with breast cancers with prepectoral edema. Thus, no association with prepectoral edema in invasive lobular carcinoma and DCIS might be explained by a lower incidence of involved axillary lymph nodes [30]. In addition, our results showed that prepectoral edema can be used to estimate the response of neoadjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 59%

Is evaluation of the presence of prepectoral edema on T2-weighted with fat-suppression 3 T breast MRI a simple and readily available noninvasive technique for estimation of prognosis in patients with breast cancer?

2013

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Lobular and non-lobular breast cancers differ regarding axillary lymph node metastasis: a cross-sectional study on 4,292 consecutive patients

Cited by 26 publications

References 26 publications

Feasibility of using negative ultrasonography results of axillary lymph nodes to predict sentinel lymph node metastasis in breast cancer patients

Feasibility of using negative ultrasonography results of axillary lymph nodes to predict sentinel lymph node metastasis in breast cancer patients

Breast Cancer in Turkey: Clinical and Histopathological Characteristics (Analysis of 13.240 Patients)

Is evaluation of the presence of prepectoral edema on T2-weighted with fat-suppression 3 T breast MRI a simple and readily available noninvasive technique for estimation of prognosis in patients with breast cancer?

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