Keratinizing pleomorphic adenoma

Abstract

Pleomorphic adenoma is the most common benign salivary gland tumour characterized by great histologic diversity. The presence of extensive squamous metaplasia and numerous keratin pearls is mostly uncommon in the microscopic study and can signify a potential pitfall in the histopathological diagnosis Pleomorphic adenoma can show the presence of squamous metaplasia with keratin pearls as a rare finding and is encountered most often in the parotid gland (84%) and 6% in the minor salivary gland. Here we present a case report of a rare histopathological variant of pleomorphic adenoma with exuberant squamous metaplasia and keratin pearl formation of the minor salivary gland in an unusual location.

A classic triphasic pleomorphic adenoma of nasal cavity mimicking as malignancy: a rare case report

“…The pathogenesis of keratin pearl formation in nasal PA is exposure of the minor salivary gland duct epithelium to various sources of irritants. 5 Histologically, PA in the upper respiratory tract may resemble aggressive epithelial tumors due to their high cellularity and absence or presence of minimal stromal component. It is important to note that this histological feature is distinct from that observed in the major salivary glands, which exhibit lower myoepithelial cellularity.…”