Keratinocyte growth factor promotes the survival, growth, and differentiation of preantral ovarian follicles

McGee, Elizabeth A.; Chun, Sang-Young; Lai, Susan; He, Youe; Hsueh, Aaron J. W.

doi:10.1016/s0015-0282(98)00547-0

Cited by 55 publications

(50 citation statements)

References 27 publications

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“…In rats, FGF7 stimulated development of primary follicles (McGee et al 1999, Kezele et al 2005 but did not do so in goats (Faustino et al 2011), whereas FGF10 stimulated primary follicle development in goats (Chaves et al 2010). Whether these discrepancies are related to different culture conditions or species is unclear.…”

Section: The Role Of the Fgf7 Family In Follicle Developmentmentioning

confidence: 99%

Mechanisms of fibroblast growth factor signaling in the ovarian follicle

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2015

Journal of Endocrinology

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Fibroblast growth factors (FGFs) have been shown to alter growth and differentiation of reproductive tissues in a variety of species. Within the female reproductive tract, the effects of FGFs have been focused on the ovary, and the most studied one is FGF2, which stimulates granulosa cell proliferation and decreases differentiation (decreased steroidogenesis). Other FGFs have also been implicated in ovarian function, and this review summarizes the effects of members of two subfamilies on ovarian function; the FGF7 subfamily that also contains FGF10, and the FGF8 subfamily that also contains FGF18. There are data to suggest that FGF8 and FGF18 have distinct actions on granulosa cells, despite their apparent similar receptor binding properties. Studies of non-reproductive developmental biology also indicate that FGF8 is distinct from FGF18, and that FGF7 is also distinct from FGF10 despite similar receptor binding properties. In this review, the potential mechanisms of differential action of FGF7/FGF10 and FGF8/FGF18 during organogenesis will be reviewed and placed in the context of follicle development. A model is proposed in which FGF8 and FGF18 differentially activate receptors depending on the properties of the extracellular matrix in the follicle.

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Section: The Role Of the Fgf7 Family In Follicle Developmentmentioning

confidence: 99%

Mechanisms of fibroblast growth factor signaling in the ovarian follicle

Price

2015

Journal of Endocrinology

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“…In contrast, mechanical isolation of follicles allows intact preantral follicles to be obtained with a centrally located oocyte surrounded by two or three layers of membrane enclosed GCs and some theca cells attached to the basal membrane (Cortvrindt et al 1996). The preantral follicles selected for in vitro culture generally measure 100 -130 mm diameter in mice (Cortvrindt et al 1996) and 130-160 mm in rats (McGee et al 1999, Zhao et al 2001a). …”

Section: Follicular Culture Systems In Micementioning

confidence: 99%

Impact of various endocrine and paracrine factors on in vitro culture of preantral follicles in rodents

Demeestere¹,

Centner²,

Gervy³

et al. 2005

Reproduction

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Folliculogenesis is a complex process regulated by various paracrine and autocrine factors. In vitro growth systems of primordial and preantral follicles have been developed for future use of immature oocytes, as sources of fertilizable oocytes and for studying follicular growth and oocyte maturation mechanisms. Rodents were often chosen for in vitro follicular culture research and a lot of factors implicated in folliculogenesis have been identified using this model. To date, the mouse is the only species in which the whole process of follicular growth, oocyte maturation, fertilization and embryo transfer into recipient females was successfully performed. However, the efficiency of in vitro culture systems must still be considerably improved. Within the follicle, numerous events affect cell proliferation and the acquisition of oocyte developmental competency in vitro, including interactions between the follicular cells and the oocyte, and the composition of the culture medium. Effects of the acting factors depend on the stage of follicle development, the culture system used and the species. This paper reviews the action of endocrine, paracrine factors and other components of culture medium on in vitro growth of preantral follicles in rodents.

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“…In vitro studies using bovine or rat follicles suggested that KGF augmented granulosa cell proliferation [3]. KGF has further been shown to promote the development of rat preantral follicles [14]. Recently, Parrot et al postulated an intriguing concept of a positive feedback loop between thecal cells and granulosa cells by demonstrating that both KGF and hepatocyte growth factor (HGF) stimulate the expression of Kit ligand (KL) in bovine granulosa cells on the one hand, and that KL stimulates the expression of KGF and HGF in thecal cells on the other hand [15].…”

Section: Resultsmentioning

confidence: 99%

Evidence for the Presence Keratinocyte Growth Factor(KGF) in Human Ovarian Follicles.

et al. 2001

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Abstract.The presence of keratinocyte growth factor (KGF) in human follicular fluid (FF) was investigated in a total of 145 FFs obtained during oocyte retrieval for in vitro fertilization (IVF) from 29 patients with no apparent endocrine disorders.The concentrations of KGF, estradiol, progesterone, testosterone and human chorionic gonadotropin (hCG) in FF were measured by enzyme-linked immunosorbent assay. FF samples contained relatively higher amounts of KGF (2194± 87 pg/ml), whereas its concentrations in serum were below assay limit (< 31.2 pg/ml). Concentrations of KGF in FF were positively correlated with both progesterone (r=0.311, p<0.0005) and testosterone (r = 0.230, p < 0.01) concentrations in FF. However, KGF concentrations were not significantly correlated with estradiol and hCG concentrations. KGF in FF was detected as a broad band (26-29 kD) by immunoblotting, the size being reduced by 7kD after N-glycosidase treatment.In an in vitro experiment, KGF suppressed the basal and hCG-stimulated progesterone production by cultured human luteinized granulosa cells. In summary, we demonstrated the presence of KGF in human ovarian follicles, suggesting its possible role as a local factor in regulating human ovarian functions.

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Keratinocyte growth factor promotes the survival, growth, and differentiation of preantral ovarian follicles

Cited by 55 publications

References 27 publications

Mechanisms of fibroblast growth factor signaling in the ovarian follicle

Mechanisms of fibroblast growth factor signaling in the ovarian follicle

Impact of various endocrine and paracrine factors on in vitro culture of preantral follicles in rodents

Evidence for the Presence Keratinocyte Growth Factor(KGF) in Human Ovarian Follicles.

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