Keratinocytes in Inflammatory Skin Diseases

Abstract

Although in the past, keratinocytes were considered simply as passive targets of immunological attack from infiltrating T lymphocytes, a number of studies have definitively demonstrated that keratinocytes actively participate in the cutaneous immune responses. Upon activation, keratinocytes express a plethora of cytokines, chemokines and accessory molecules, which can transmit both positive and negative signals to cells of innate and adaptive immunity. Dysregulation and abnormal expression of inflammatory mediators or their receptors in keratinocytes are relevant to the pathogenesis of chronic inflammatory skin diseases such as psoriasis, atopic dermatitis and allergic contact dermatitis.

Abnormális STAT1 aktivitás pikkelysömörben

“…A STAT1 az IFN, az IL-27, az IL-35 és a TLR közvetített jelátvitelen keresztül aktiválódik (19). Számos tanulmány beszámol az IFNγ jelátvitel fontosságáról a pikkelysömör patomechanizmusában (20). A STAT1 szá-mos gén transzkripciós aktivációját okozza, míg más gé-nek expresszióját antagonista módon befolyásolja, így kialakítva egy komplex szignál választ (21).…”

Honey: an immunomodulatory agent for disorders of the skin

“…The skin immune system is comprised of a complex network of cells, molecules and physical barriers that prevent infection and maintain skin health. Skin cells called keratinocytes play an important function in protecting the skin from infection and also play a role in the pathophysiology of certain skin diseases (Albanesi, Scarponi, Giustizieri & Girolomoni, 2005). Keratinocytes can recognise foreign microbes via toll-like receptors expressed on their surface and release cytokines and anti-microbial peptides (AMPs) in response.…”

Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” <i>in Vitro</i> Reconstructed Epidermis

“…Other authors postulate thatkeratinocytes aretargets of T lymphocytes infiltrating immune processes, to have an active role in atopic dermatitis. Its role in maintaining homeostasis and proper functionality of the skin is essential not only for the correct expression of proteins that ensure epithelial structure, but for the production of lipids that prevent the loss of water and production of cytokines involved in activation and cell chemotaxis processes (inflammation), in proliferation and differentiation [26] [27].…”