Keratins in wound healing

Kelly, Robert

doi:10.1016/b978-1-78242-456-7.00017-9

Cited by 24 publications

(20 citation statements)

References 24 publications

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“…A clinical study on the use of dressings, containing wool-derived keratin, on refractory wounds of different origin supported the effect of keratin, with an overall response rate of 82% and a healing rate of 64% (4). Likewise, keratin products were shown to promote healing with minimal scarring in superficial and partial thickness burn injuries as well as being useful in the treatment of the lesions of patients with epidermolysis bullosa (6,7,11).…”

Section: Keratin Gel As An Adjuvant In the Treatment Of Recalcitrant mentioning

confidence: 89%

Keratin Gel as an Adjuvant in the Treatment of Recalcitrant Pyoderma Gangrenosum Ulcers: A Case Report

Paulsen

Bygum

2019

Acta Derm Venerol

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Section: Keratin Gel As An Adjuvant In the Treatment Of Recalcitrant mentioning

confidence: 89%

Keratin Gel as an Adjuvant in the Treatment of Recalcitrant Pyoderma Gangrenosum Ulcers: A Case Report

Paulsen

Bygum

2019

Acta Derm Venerol

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“…Polyvinyl alcohol (PVA) is a popular polymer used because of its biocompatibility and its ability to provide a conducive environment for skin regeneration. This polymer lacks other functional groups and cell recognition sites for functionality at the cellular level is therefore used in combination with bioactive composites like keratin to enhance cell adhesion and faster skin repair [8,21]. This new developed electrospun nanofibers combine the biocompatibility potential of PVA, with the bioactive nature of keratin and CoQ10 and the antibacterial property of mupirocin as a new potential for proper wound care.…”

Section: Discussionmentioning

confidence: 99%

“…A good candidate for this purpose is keratin, due to its good bioactive potentials which support cell viability, cell attachment, and proliferation [6,7]. Keratin has the ability to activate keratinocytes in the wound bed, stimulating them to proliferate and migrate leading to eventual wound closure [8].…”

Section: Introductionmentioning

confidence: 99%

Development of electrospun keratin/coenzyme Q10/poly vinyl alcohol nanofibrous scaffold containing mupirocin as potential dressing for infected wounds

et al. 2020

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Background: Nanostructured wound dressings produced by electrospinning biocompatible polymers possess great potential because they resemble the natural extracellular matrix and support cell adhesion, proliferation, and differentiation. This study seeks to fabricate mupirocin, keratin, and coenzyme Q10 (Co Q10)-loaded PVA electrospun scaffolds intended for wound healing application and to characterize their morphology, physical properties, antibacterial activity, and biocompatibility. Polyvinyl alcohol (PVA) (10% w/v), various concentrations of keratin/Co Q10 fibrous scaffolds (electrospun at a voltage of 50 kV, flow rate of 4 mL/h), and 2% mupirocin was designed and fabricated to activate keratinocytes in the wound bed, stimulate cell proliferation, and increase antimicrobial penetration. Results: The diameters of the scaffolds were observed to be in the nanoparticulate range 2.11 ± 0.20 to 3.27 ± 0.10 nm. By 30 min, all the scaffolds had more than 50% of the cumulative concentration of mupirocin released with 51.06 ± 2.104% to 74.66 ± 1.72% of mupirocin released. At 1 h, 80% of the mupirocin in the scaffold was seen to have diffused out of the scaffold. Release of mupirocin was modulated; an initial burst release was followed by sustained release over 2 h. Electrospun keratin/Co Q10/PVA scaffold containing mupirocin showed excellent antimicrobial activity against all the clinical isolates of 2586, Staphylococcus aureus 2590, 2583, 2587, 2555. All the electrospun scaffolds showed higher cell viability values than the control at 48 and 72 h, with the optimized CoQ10 scaffold concentration being 0.05% w/w. Conclusion: Electrospun nanofibers combining the biocompatibility potential of PVA with the bioactive nature of keratin (0.01% w/w) and CoQ10 (0.5% w/w) and the antibacterial property of mupirocin as a new potential for proper wound care was successfully developed. The cell line studies on this electrospun scaffold (PKCM 3) showed their ability to support the growth of keratinocytes hence the potential of developed scaffolds as a wound dressing. In vivo studies to further investigate the applications of the electrospun keratin/Co Q10/PVA nanofibrous scaffold as a wound dressing is however required.

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“…Keratin are proteins derived from human hair, wool, feathers, horns, hooves and nails. Due to their unique characteristics of bioactivity, biocompatibility, biodegradability, and natural abundance, keratin have been widely developed in wound healing applications [ 67 ]. Carboxyl groups are present in keratin structure, and the mechanism of swelling in response to the media pH change would be a protein structural reorganization driven by carboxyl protonation/deprotonation [ 68 ].…”

Section: Polymer-based Smart Drug Delivery Systems For Topical Applicationsmentioning

confidence: 99%

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

et al. 2021

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Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

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Keratins in wound healing

Cited by 24 publications

References 24 publications

Keratin Gel as an Adjuvant in the Treatment of Recalcitrant Pyoderma Gangrenosum Ulcers: A Case Report

Keratin Gel as an Adjuvant in the Treatment of Recalcitrant Pyoderma Gangrenosum Ulcers: A Case Report

Development of electrospun keratin/coenzyme Q10/poly vinyl alcohol nanofibrous scaffold containing mupirocin as potential dressing for infected wounds

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

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