Keratitis due to Nocardia nova after cataract surgery

Prieto-Borja, Laura; García-Coca, Marta; Ustratova, Iuliia; Alba, Nicolás Alejandre

doi:10.1016/j.eimc.2016.06.004

Cited by 5 publications

(8 citation statements)

References 9 publications

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“…Surgical trauma is one of the most common risk factors for Nocardia ocular infection. Former reports of Nocardia infection after surgeries mostly involved single cases, such as Femtosecond Laser-Assisted Lamellar Keratectomy and cataract surgery [5,[10][11][12] . This paper reported eight Nocardia infection cases following ocular surface surgery: three patients with pterygium excision, three patients undergoing conjunctival ap covering, and two patients subjected to lamellar corneal transplantation.…”

Section: Discussionmentioning

confidence: 99%

“…Trauma, [2] topical steroid use, [3] ocular surgery, and contact lens wearing are common risk factors associated with ocular nocardiosis. [4,5] Postoperative infections, especially following surface surgery caused by Nocardia, are rare and reported mostly in single cases. [6,7] This retrospective study was performed to analyze the clinical characteristics and treatment outcomes of Nocardia infection following ocular surface surgery, contributing to a deeper understanding of the disease and its clinical diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

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Nocardia infection following ocular surface surgery

Wang

et al. 2022

Preprint

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Objective: To investigate the clinical characteristics and treatment outcomes of Nocardia infection after ocular surface surgery. Methods: This is a retrospective study. Eight cases of culture-proven Nocardia infection, which developed within one month after ocular surface surgery were included. Demographics and clinical history of patients were investigated. Results: There were 8 eyes (2 left and 6 right) of 8 patients (5 males and 3 females), aged 27-65, with a median age of 52.9 years. Three cases underwent pterygium excision, three were subjected to conjunctival flap covering, and two were treated with lamellar corneal transplantation. The time interval between previous surgery and the onset of symptoms varied from 7 to 28 days (mean = 20.5 ± 7.13 days). All the cases presented grey-white infiltrates at the surgical incision site while appearing with six corneal ulcers and two conjunctival ulcers. Filaments of Nocardia were founded by confocal microscopy in two of the five cases. All responded poorly to medical therapy. Seven of the eight cases were treated with reoperation. Nocardia infection recurred in three cases after reoperation, and one was eviscerated.Conclusions: Surgical trauma is a risk factor for ocular Nocardia infection. Nocardia infection should be suspected when secondary infection occurs in a surgical incision with an atypical clinical presentation. Complete removal of lesions may lower the recurrence of Nocardia infection with poor drug treatment effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nocardia infection following ocular surface surgery

Wang

et al. 2022

Preprint

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“…The authors found a male predominance. Another study reported a corneal ulcer with N. nova 48 days after uncomplicated cataract surgery [21]. The authors treated the ulcer successfully with oral co-trimoxazole and topical amikacin and moxifloxacin.…”

Section: Risk Factorsmentioning

confidence: 99%

Current diagnostic tools and management modalities of Nocardia keratitis

Soleimani

Masoumi

Khodavaisy

et al. 2020

J Ophthal Inflamm Infect

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Nocardia species are an uncommon but important cause of keratitis. The purpose of this review is to discus previous published papers relation to the epidemiology, etiology, diagnosis and management of Nocardia keratitis. Nocardia asteroides is the most frequently reported from Nocardia keratitis. Pain, photophobia, blepharospasm and lid swelling are mainly clinical manifestations. Usual risk factors for Nocardia keratitis are trauma, surgery, corticosteroids, and contact lens wear. Several antibiotics were used for treatment of Nocardia infection but according to studies, topical amikacin is the drug of choice for Nocardia keratitis. Topical steroid should not prescribe in these patients. In conclusion, although Nocardia keratitis is rare, early diagnosis and treatment are essential to prevent any scar formation and preserve a good visual acuity.

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“…Ocular Nocardia infections are rare, with a global prevalence below 2%. 1 The majority of Nocardia keratitis cases are secondary to trauma, 1 – 5 contact lens use, 6 – 12 or iatrogenic 13 – 15 causes. Given the diversity, 16 – 19 regionality, 20 rarity, and inexperience 21 with this organism, it is often misdiagnosed.…”

Section: Introductionmentioning

confidence: 99%

Rose Bengal and Riboflavin Mediated Photodynamic Antimicrobial Therapy Against Selected South Florida Nocardia Keratitis Isolates

Adre

Durkee

Arboleda

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose To examine and compare the efficacy of in vitro growth inhibition using rose bengal and riboflavin photodynamic antimicrobial therapy (PDAT) for Nocardia keratitis isolates. Methods Nocardia asteroides complex, Nocardia amikacinitolerans , and Nocardia farcinica species were isolated from patients with confirmed Nocardia keratitis. Isolates were tested against three experimental groups: (1) no photosensitizer/no irradiation, (2) photosensitizer/no irradiation, and (3) photosensitizer/irradiation. Each isolate was prepared in suspension to a concentration of 1.5 × 10 8 CFU/mL. Bacterial suspensions were mixed with water or prepared 0.1% photosensitizer solution for a final bacterial concentration of 1.5 × 10 7 CFU/mL. Aliquots of 1 mL were plated on 5% sheep blood agar. Rose bengal and riboflavin PDAT plates were irradiated for 15 minutes with a 525- or 375-nm custom 6-mW/cm 2 powered light source for a total fluence of 5.4 J/cm 2 . All experimental groups were repeated in triplicate. Plates were incubated in a 35°C non-CO 2 incubator for 96 hours and photographed. Percent inhibition was evaluated using LabVIEW-based software. Results All strains of Nocardia tested with 0.1% rose bengal and irradiated for 15 minutes demonstrated statistically significant inhibition of growth ( P < 0.05). No other experimental groups displayed any bacterial inhibition. Conclusions Rose bengal is superior to riboflavin PDAT against selected Nocardia isolates . In vivo testing is warranted to investigate the utility of rose bengal PDAT for severe Nocardia keratitis. Translational Relevance In vitro results for three clinical strains of Nocardia support the possible use of rose bengal PDAT as a complementary treatment of Nocardia keratitis .

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Keratitis due to Nocardia nova after cataract surgery

Cited by 5 publications

References 9 publications

Nocardia infection following ocular surface surgery

Nocardia infection following ocular surface surgery

Current diagnostic tools and management modalities of Nocardia keratitis

Rose Bengal and Riboflavin Mediated Photodynamic Antimicrobial Therapy Against Selected South Florida Nocardia Keratitis Isolates

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