Keratoconus: a potential risk factor for osteoarthritis

Bozkurt, Erdinç; Bağcıer, Fatih

doi:10.1007/s10792-020-01434-0

Cited by 4 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…KC, which usually shows bilateral asymmetric involvement, can be asymptomatic at the beginning, and visual acuity decreases as the disease progresses [1,2]. Although some systemic involvement of KC is shown, it is generally known as a local corneal disease [5,6]. Abnormalities in the corneal epithelium, Bowman's layer and especially the collagen structure of the stroma play a role in the pathogenesis of the disease.…”

Section: Introductionmentioning

confidence: 99%

Advances in Non-surgical Treatment Methods in Vision Rehabilitation of Keratoconus Patients

Muhafız¹

2021

Eyesight and Medical Image Cognition - Recent Advances and New Perspectives [Working Title]

View full text Add to dashboard Cite

Visual acuity decreases due to progressive irregular astigmatism in keratoconus (KC). Although glasses can be useful in the initial stages of vision rehabilitation, contact lenses (CL) are needed in many patients due to irregular astigmatism. Although rigid gas permeable (RGP) CLs provided the patient with a better visual acuity than glasses, their effects on corneal tissues and caused comfort problems. Although soft CL produced for KC have solved some of these problems, they could not increase visual acuity as much as RGPs in advanced stage KC. For this reason, new searches for vision rehabilitation and comfort in KC have continued. In this context, piggyback contact lenses (PBCL) have been used in vision rehabilitation. Hybrid CLs have gained popularity due to the fact that PBCLs cause corneal neovascularization and giant papillary conjunctivitis. Scleral CLs have been developed for limited benefit in some patients with advanced KC. Scleral CLs provided good vision rehabilitation. The biggest problem of scleral CLs is the application and removal difficulty. All these CL modalities try to improve the quality of life and delay surgical procedures by increasing the level of vision in patients with KC.

show abstract

Section: Introductionmentioning

confidence: 99%

Advances in Non-surgical Treatment Methods in Vision Rehabilitation of Keratoconus Patients

Muhafız¹

2021

Eyesight and Medical Image Cognition - Recent Advances and New Perspectives [Working Title]

View full text Add to dashboard Cite

show abstract

“…O steoarthritis (OA) is a chronic degenerative joint disease characterized by pathological changes in joint structure, such as cartilage erosion and synovial inflammation. 1,2 Currently, there is no effective therapy to change the pathological progression of OA. Therefore, exploring the pathogenesis and contributing factors of OA is of great significance for the treatment of OA.…”

mentioning

confidence: 99%

Associations of Blood Cadmium Levels With Osteoarthritis Among US Adults in NHANES 2013–2018

Li,

Cao,

et al. 2024

J Occup Environ Med

View full text Add to dashboard Cite

Background Osteoarthritis is a global public health problem, and limited information is available on the effects of Cd on OA. The purpose of this study is to explore the relationship between Cd and OA. Method Weighted multivariable logistic regression model, trend test, restricted cubic spline (RCS) and stratified analysis were used to study the association between BCd and OA. Results: In the two regression models of weighted multivariable logistic regression analysis, the correlation between BCd and OA was positive. Compared to the lowest quartile of BCd exposure, the highest quartile had a 2.03-fold (95%CI: 1.67,2.47), displaying a dose−response relationship (P for trend <0.00001). The restrictive cubic spline shows a positive linear relationship between BCd and OA. Conclusion There was a positive linear relationship between BCd and OA, and a dose-response relationship.

show abstract

Genetic Estimates of Correlation and Causality Between Keratoconus and Osteoarthritis

Han,

Liu

et al. 2024

Cornea

View full text Add to dashboard Cite

Purpose: The relationship between keratoconus (KC) and osteoarthritis (OA) has been hypothesized, yet the causal link remained obscure. We aimed to evaluate the genetic correlation and causality between KC and OA through a genetic perspective. Methods: Linkage Disequilibrium Score Regression and bidirectional 2-sample Mendelian randomization (MR) analysis were conducted. Data were used from genome-wide association study on KC (4669 cases and 116,547 controls), OA (encompassing 24,955 patients with knee OA, 15,704 patients with hip OA, 39,427 patients with knee or hip OA, and 378,169 control participants), and KC data in the FinnGen consortium for replication and meta-analysis. Simple model, weighted model, inverse-variance weighted, weighted median, and MR-Egger regression were employed to assess the causal effects. MR pleiotropy residual sum and outlier method, MR-Egger method, and leave-one-out analysis were also applied to detect pleiotropy. Results: No statistically significant genetic correlation between KC and OA (all P > 0.05) were observed. MR estimates obtained from all 5 methods after meta-analysis revealed nonsignificant odds ratio values of KC-related traits to knee OA, hip OA, and OA (all adjusted P > 0.05). No evidence of causal relationships of knee and hip OA with KC-related traits was detected after meta-analysis of all 5 MR methods (all adjusted P > 0.05). Conclusions: The large MR analysis indicated that KC may not be causally associated with a risk of OA.

show abstract

Keratoconus: a potential risk factor for osteoarthritis

Cited by 4 publications

References 24 publications

Advances in Non-surgical Treatment Methods in Vision Rehabilitation of Keratoconus Patients

Advances in Non-surgical Treatment Methods in Vision Rehabilitation of Keratoconus Patients

Associations of Blood Cadmium Levels With Osteoarthritis Among US Adults in NHANES 2013–2018

Genetic Estimates of Correlation and Causality Between Keratoconus and Osteoarthritis

Contact Info

Product

Resources

About