Keratoconus, cross-link-induction, comparison between fitting exponential function and a fitting equation obtained by a mathematical model

Albanese, Antonietta; Urso, R.; Bianciardi, Laura; Rigato, M.; Battisti, Emilio

doi:10.1016/j.biopha.2009.08.001

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The curvature and thickness of the cornea play an important role in focusing the light to the lens; therefore, they are largely responsible for its optical powers (1) . In humans and many other mammals, the cornea consists of five layers: the epithelium, Bowman's membrane, the stroma, Descemet's membrane, and the endothelium (2) .…”

Section: Introductionmentioning

confidence: 99%

Finite element modelling of cornea mechanics: a review

Nejad

Foster

Gongal

2014

Arquivos Brasileiros De Oftalmologia

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The cornea is a transparent tissue in front of the eye that refracts light and facilitates vision. A slight change in the geometry of the cornea remarkably affects the optical power. Because of this sensitivity, biomechanical study of the cornea can reveal much about its performance and function. In vivo and in vitro studies have been conducted to investigate the mechanics of the cornea and determine its characteristics. Numerical techniques such as the finite element method (FEM) have been extensively implemented as effective and noninvasive methods for analyzing corneal mechanics and possible disorders. This article reviews the use of FEM for assessing the mechanical behavior of the cornea. Different applications of FEM in corneal disease studies, surgical predictions, impact simulations, and clinical applications have been reviewed. Some suggestions for the future of this type of modeling in the area of corneal mechanics are also discussed.

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Section: Introductionmentioning

confidence: 99%

Finite element modelling of cornea mechanics: a review

Nejad

Foster

Gongal

2014

Arquivos Brasileiros De Oftalmologia

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Embedded Collagen Deformation Models for Computational Modeling of Healthy, Keratoconic, and Crosslinked Corneas

Foster

Gongal

Begaj

et al. 2013

J. Mech. Med. Biol.

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Collagen plays an extremely important role in carrying forces and maintaining the shape of the cornea. In keratoconus, the cornea shape can become distorted to the extent that normal vision is impossible, and the amount crosslinking between collagen fibrils are generally lower than in healthy eyes. In contrast, riboflavin-induced crosslinks can strengthen and stiffen the cornea. This article examined quantitatively how the extent of crosslinking in collagen fibrils influences the overall mechanical behavior of corneal tissue. Three models for the stress–strain behavior of the fibrils were examined, which is a function of the crosslink density within the fibrils. These models were then embedded in a matrix model, and tensile tests of cornea strips were examined using a finite element program. Results were compared with experiments from the literature for both normal and crosslinked corneas.

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Keratoconus, cross-link-induction, comparison between fitting exponential function and a fitting equation obtained by a mathematical model

Cited by 2 publications

References 7 publications

Finite element modelling of cornea mechanics: a review

Finite element modelling of cornea mechanics: a review

Embedded Collagen Deformation Models for Computational Modeling of Healthy, Keratoconic, and Crosslinked Corneas

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