An analytical method in a quasi-static fiber grating sensing system under transverse uniform press is proposed based on genetic algorithm The effect of population size, generations, crossover ratio and mutation ratio to genetic algorithm, and the optimization parameters of genetic algorithm were given. The relevant experimental system is constructed. The simulation and experiments show that the analytical method proposed can be applied to analyze the reflective spectra of the quasistatic FBG sensing system at transverse uniform press, the strain measurement with high-precision of 0.91% can be realized CLC numbers: TN253 Document code: A