Acne is a skin disease that can be associated physical and psychological problems. Psychological problems result from feelings of social isolation, low self-esteem, social inavailability, and social withdrawal. Psychological well-being is a healthy, fully operational mental and mental health condition of the individual. Previous studies linked the relationship of religious and psychological well-being. Religiosity is the depth of religious thought and internalization in daily life. This study aimed to identify the role of religiosity in psychological well-being of early female females suffering from acne problems. This study used a quantitative method with a total of 306 women who were in an age range of 20 -40 years and experienced acne problems. Participants were selected using nonprobability sampling with purposive sampling technique. Based on the results, researcher found that religiosity has a role in psychological well -being, with R² = 0.139, p = 0.0000 <0.05. This shows that religiosity has a role of 13.9% on psychological well-being, and 86.1% is influenced by other factors. The dimension of religiosity that played the most role on psychological well-being in this study was religious experience with a percentage of 13.4%.