Kesesuaian Tata Laksana Psoriasis Dengan Panduan Praktik Klinis (Ppk) Di Rsupn Dr. Cipto Mangunkusumo

Budianti, Windy Keumala; Anindya, Shafira; Debinta, Arlha Aporia; Novianto, Endi; Fitri, Eyleny Meisyah; Halim, Evita

doi:10.33820/mdvi.v46i4.77

Cited by 5 publications

(11 citation statements)

References 5 publications

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“…The toxic effects of methotrexate need to be considered during psoriasis therapy. 17 NSAIDs, penicillin, and trimethoprim. 17,18 Table 2 shows that the treatment of psoriasis vulgaris using oral methotrexate reduced the PASI score quite well by 6.00+2.47.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy

Rosmarwati

Mulianto²,

Febrianto³

et al. 2022

BIKK

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Background: Psoriasis Vulgaris is an autoimmune disease characterized by chronic skin inflammation and epidermal hyperplasia. Psoriasis Area Severity Index (PASI) score is one of the assessments to measure the psoriasis severity. Oral methotrexate is one of the effective therapies for psoriasis patients. Narrow Band-Ultraviolet B (NB-UVB) phototherapy is an adjunctive psoriasis therapy given concurrently with oral methotrexate. Purpose: Determine the difference in Psoriasis Area Severity Index (PASI) scores between Psoriasis Vulgaris patients treated with oral methotrexate and a combination of oral methotrexate and NB-UVB phototherapy. Methods: This observational analytic study was conducted at the Dermatology and Venereology Clinic, Dr. Moewardi General Hospital Surakarta. The patients received oral methotrexate and a combination of oral methotrexate and and Narrow Band-Ultraviolet B (NB-UVB) phototherapy. A retrospective study of medical records was conducted to determine the patient's PASI score before the therapies and 3 months after. All data were analyzed with the Shapiro Wilk normality test and the independent T-test. A p-value was <0.05, and it was considered significant. Result: The mean of decreased PASI scores in the oral methotrexate group was (6.00 +2.47) and (6.08 +2.17) in the combination therapy group. Based on the statistical test results from the 24 subjects, it was found that the PASI score decreased (p=0.931). Conclusion: There was no significant difference in the decrease in PASI between the oral methotrexate group and the combination therapy group. The mean reduction of PASI scores was more significant in the combination therapy than in the methotrexate group

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Section: Discussionmentioning

confidence: 99%

“…17 NSAIDs, penicillin, and trimethoprim. 17,18 Table 2 shows that the treatment of psoriasis vulgaris using oral methotrexate reduced the PASI score quite well by 6.00+2.47. The results of this study follow previous research by Haider et al in 2014 in Pakistan.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy

Rosmarwati

Mulianto²,

Febrianto³

et al. 2022

BIKK

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“…Psoriasis vulgaris (PV) adalah penyakit kulit inflamasi kronis dengan kerentanan genetik (Budianti and Anindya, 2019;Gudjonsson and Elder, 2019). Penyakit ini ditandai dengan adanya plak bersisik merah yang biasa terjadi pada siku, lutut, kulit kepala, dan punggung bagian bawah (Parisi dkk., 2020).…”

Section: Pendahuluanunclassified

“…PV memiliki dampak psikososial yang signifikan dan menurunkan kualitas hidup pasien. Kulit penderita psoriasis akan terlihat kering dan bersisik akibat percepatan proliferasi keratinosit dan dapat menyebar ke seluruh tubuh membentuk eritroderma psoriasis (Budianti and Anindya, 2019). PV saat ini diketahui memiliki hubungan erat dengan penyakit penyerta seperti artritis psoriasis, obesitas, penyakit kardiovaskular, penyakit hati non-alkohol, sindrom metabolik, penyakit radang usus, dan kondisi kesehatan mental yang dapat memperburuk kualitas hidup dan mengurangi harapan hidup pasien (Armstrong, Harskamp andArmstrong, 2012, 2013;Coates and Helliwell, 2017;Liang, Cohen and Ho, 2019;Armstrong dkk., 2021).…”

Section: Pendahuluanunclassified

“…Tujuan terapi PV adalah untuk mencegah kekambuhan, menghindari pencetus, dan meningkatkan kualitas hidup, sehingga pemberian terapi dapat dimodifikasi secara individual. Selain mengidentifikasi jenisnya, tingkat keparahan PV perlu ditentukan untuk memilih perawatan yang tepat (Budianti and Anindya, 2019). Berdasarkan Panduan Praktik Klinis (PPK) Rumah Sakit Dr. Cipto Mangunkusumo (RSCM) dan Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI), klasifikasi psoriasis berdasarkan skor BSA/PASI adalah sebagai berikut; <3% psoriasis ringan, 3-10% psoriasis sedang, >10% psoriasis berat.…”

Section: Pendahuluanunclassified

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Pengaruh Pemberian Platelet-Rich Plasma Terhadap Derajat Keparahan Psoriasis Vulgaris

Earlia¹,

Yunita²,

_³

et al. 2023

j med sci

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Psoriasis vulgaris is an autoimmune disease that is influenced by multifactor, namely environmental, genetic (HLA-Cw6), and immune system dysregulation (IL-17 or IL-22), resulting in increased proliferation of keratinosit in the epidermis. Histologically characterized by parakeratosis, hyperkeratosis, elongated rete ridge, Monro micro abscess, and Kogoj micro abscess. The clinical picture is red patches with thick scales, especially in the trauma area. Platelet Rich Plasma (PRP) is an autologous preparation of platelets that strengthens in plasma and is a powerful anti-inflammatory agent. The immunomodulatory and anti-inflammatory effects of PRP are believed to play a role in the treatment of chronic inflammation patients. One of the important mediators in the pathogenesis of psoriasis is nuclear factor kappa B (NF-κB) and PRP exerting an inhibitory effect on NF-κB. The aim of the study was to assess the effect of PRP on the severity and quality of life of psoriasis vulgaris patients. The design of this study is a paired numerical comparative analysis using two groups with two measurements. The research design was a randomized, undisguised clinical trial and a parallel design. The study lasted for 6 weeks. Sampling was done by total sampling involving 20 psoriasis Vulgaris patients, then divided into two groups: intervention group and control group. The test group received 2 PRP injections and topical combination therapy (salicylic acid 3% + Vaseline album cream), while the control group only received topical combination therapy. The results of this study found a decrease in PASI and DLQI scores in the intervention group compared to the control group (p<0.005). This study concludes that the administration of PRP can reduce the severity of psoriasis Vulgaris as well as improve the quality of life of psoriasis Vulgaris patients.

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Generalized Pustular Psoriasis in Childhood: A Rare Case

Asnawi,

Maulida,

Earlia

et al. 2023

BIKK

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Background: Generalized pustular psoriasis (GPP) rarely occurs under 10 years of age. GPP is typically characterized by an eruption of generalized pustules accompanied by systemic symptoms such as fever for several days, malaise, and anorexia. Pustules are sterile, with a size of 2-3 mm, and spread over the trunk and extremities. This disease can be life-threatening; therefore, optimal therapy is required. Purpose: to report a rare case of GPP in childhood. Case: A 4-year-old girl with complaints of widespread red patches that spread to her neck, back, and hands, with red patches turning into streaks that are partially pus-filled and itchy. In almost all parts of the body, skin abnormalities were seen in the form of generalized erythematous plaques, well-defined borders, multiple pustules on the edges, and some plaques covered by thick scales and crusts. In the calculation of body surface area (BSA), the result is 44%, and in the calculation of generalized pustular psoriasis area and severity index (GPPASI), the result is 21.30. The patient was treated with combination topical therapy of 3% salicylic acid, desoximethasone cream 0.25%, momethasone cream 0.1% vaseline albume as emollients, and coal tar. Significant improvement was seen after 1 month of therapy. Discussion: GPP in children is a rare case. GPP is idiopathic and can be life-threatening. Until now, there has been no standard therapy that is considered the most effective and safe for children. Topical therapy may be an option.

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Kesesuaian Tata Laksana Psoriasis Dengan Panduan Praktik Klinis (Ppk) Di Rsupn Dr. Cipto Mangunkusumo

Cited by 5 publications

References 5 publications

Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy

Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy

Pengaruh Pemberian Platelet-Rich Plasma Terhadap Derajat Keparahan Psoriasis Vulgaris

Generalized Pustular Psoriasis in Childhood: A Rare Case

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