Ketamine as Adjuvant for Acute Pain Management

Imani, Farnad; Varrassi, Giustino

doi:10.5812/aapm.100178

Cited by 50 publications

(47 citation statements)

References 20 publications

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“…2020; 10(2):e103624. cal use and good safety profile (11)(12)(13). Physiotherapy seems somewhat interesting, as much as educational programs are presented, especially for working adults (14,15).…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Neuromodulation of Suprascapular Nerve in Chronic Shoulder Pain: A Case Report

et al. 2020

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Shoulder pain is very frequent, especially in middle-aged male adults. Its treatment may be very problematic, mainly in patients who cannot rest and stop their work. At present, it is treated with analgesics, physiotherapy, infiltration of corticosteroids, and/or radiofrequency neuromodulation of the suprascapular nerve. This may be effective but not easy to do. Its efficacy is limited in time, especially because the approach to the nerve trunk may be problematic for its anatomical nature. Ultrasonography has helped, but it is not always completely helpful, due to the small dimension and the complexity of the anatomical structure. In this case report, we describe a more helpful approach to the nerve trunk using an endoscopic technique. The results are very promising. However, larger studies would be necessary to make clear its usefulness.

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Section: Discussionmentioning

confidence: 99%

Endoscopic Neuromodulation of Suprascapular Nerve in Chronic Shoulder Pain: A Case Report

et al. 2020

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“…First, chronic pain patients usually consult pain clinics when their pain problem interferes with their lives, or their pain intensity should be at least severe enough to urge them to seek treatment. Second, the available analgesics for acute pain might be more effective than chronic pain management modalities because multimodal and preventive analgesia are well indicated and administered in acute post-op pain settings ( 15 ). Consequently, acute pain management could be more effective.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Chronic Pain on Number Sense and Numeric Rating Scale: A prospective Cohort Study

et al. 2020

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Background: Several studies have demonstrated an association between chronic pain and impairment of cognitive capabilities. Since the number sense is one of the cognitive ability involved in the evaluation of pain intensity using some pain measurement tools, impairment of number sense may impact pain assessment. Therefore, the validity of number-based pain assessment tools should be re-evaluated. Objectives: This study aimed to determine whether number sense is altered in chronic and acute pain patients compared to healthy subjects. Methods: Overall, 150 participants were recruited and divided into the three groups of controls, chronic and acute pain patients. Pain intensity was evaluated using numeric and verbal rating scales as pain assessment tools. Number sense was assessed using number naming, number marking, and line bisection tasks. Deviation from correct answers was measured for each task. Results: Patients with chronic pain (migraine headache) had higher pain intensity scores than acute pain subjects. Chronic pain patients showed significant deviation from the expected responses compared to controls in the line bisection task. Conclusions: Chronic pain patients may have impaired number sense and may differently use number-based pain assessment tools in comparison with healthy individuals.

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“…The results showed that VAS changes were greater after 30 min in the ketamine group (29.0 mm) compared to the metoclopramide-diphenhydramine group (22.2 mm) (20). One of the most important advantages of ketamine is its various prescription methods (20,37). The Ketamine acts through various mechanisms, including the supraspinal mechanisms, cholinergic and monoamine effects, local anesthetic action, sigma receptor interaction, and NMDA receptor antagonism (34).…”

Section: Discussionmentioning

confidence: 99%

Comparison the Efficacy of Intranasal Ketamine Versus Intravenous Ketorolac on Acute Non-Traumatic Headaches: A Randomized Double-Blind Clinical Trial

Sarvari

Baigrezaii

Nazarianpirdosti

et al. 2020

Preprint

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Introduction: Non - traumatic headaches are one of the most common causes of referral to hospital emergency. This study aimed to compare the efficacy of intranasal ketamine and intravenous ketorolac on acute non-traumatic headaches.Methods: This randomized and double-blind clinical trial in 2019 years. 140 people were randomly divided into intranasal ketamine (A) and intravenous ketorolac (B). Group (A) received ketamine intranasal (0.75 mg/kg, max 75mg), and group B received intravenous ketorolac (30 mg). Headache severity was measured on arrival, 30, 60, and 120 minutes after intervention with Visual Analogue Scale (VAS). The side effects were recorded an hour after the intervention.Result: The mean difference of pain intensity 30, 60, and 120 minutes after the intervention between the two groups were statistically significant (p<0.001). In the first 30 minutes, significant changes were observed in the VAS levels of the two groups. These changes were more and significant in the intranasal ketamine group (p <0.001). Side effects such as fatigue, dizziness, public discomfort, nausea, increased heart rate, and hypertension were significantly higher in the ketamine group (p <0.05).Conclusion: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches. However, more analgesic effects of intranasal ketamine in a short time can be considered as a selective approach to reducing headaches.

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Ketamine as Adjuvant for Acute Pain Management

Cited by 50 publications

References 20 publications

Endoscopic Neuromodulation of Suprascapular Nerve in Chronic Shoulder Pain: A Case Report

Endoscopic Neuromodulation of Suprascapular Nerve in Chronic Shoulder Pain: A Case Report

The Influence of Chronic Pain on Number Sense and Numeric Rating Scale: A prospective Cohort Study

Comparison the Efficacy of Intranasal Ketamine Versus Intravenous Ketorolac on Acute Non-Traumatic Headaches: A Randomized Double-Blind Clinical Trial

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