Ketamine-based analgosedation for dressing changes in burn patients

Abstract

by two-fold to three-fold, 5 may be a key factor influencing the therapeutic effects of other potential therapeutic interventions like TTM in the postresuscitation period. We therefore analysed all available data from larger clinical trials, focusing on therapeutic hypothermia and TTM, 2-4 and compared bystander CPR rates and the effects of TTM. Results from the analysis of pooled data from these publications support the hypothesis that populations with lower bystander CPR rates benefit much more from TTM than those with very high bystander-CPR rates (Fig. 1). From our results we thus conclude that therapeutic hypothermia and TTM may not be effective when administered following very short periods of cardiac arrest -due to very high bystander CPR rates -consequently resulting in only mild cerebral insults. In addition, with a very late onset of reaching target temperature, 3,4 the application of TTM may have been outside the window of therapeutic opportunities. 1 Further studies may investigate this most important relationship.

Ketamine-based analgosedation for dressing changes in burn patients

“…We would like to thank Deniau and colleagues 1 for their interest in our article. 2 They raise several issues regarding…”

“…We read with great interest the short scientific report by McClune et al 1 on the ketamine-based analgosedation for dressing changes in severely burned patients. We would like to congratulate the authors for this very interesting and well performed observational study.…”

Reply to: Ketamine-based analgosedation for dressing changes in burn patients

“…We would like to thank Deniau and colleagues 1 for their interest in our article. 2 They raise several issues regarding Ketamine total dose (mg)…”

“…We would like to thank Deniau and colleagues 1 for their interest in our article 2 . They raise several issues regarding the use of ketamine and the potential risk of secondary sclerosing cholangitis (SSC).…”

“…In our institution ketamine is used by intermittent boluses (0.5 to 1 mg kg −1 ) to facilitate analgosedation for burn dressing changes 2 . Thus, one of our study's objectives was to evaluate if such doses of ketamine were an effective and safe medication for this use.…”