Ketamine blockade of cortical spreading depression in rats

Gorelova, Natalia; Koroleva, V. I.; Amemori, Takashi; Pavlík, V.; Bureš, Jan

doi:10.1016/0013-4694(87)90213-6

Cited by 117 publications

(34 citation statements)

References 17 publications

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“…However, we were unable to succeed in suppressing cortical activity as determined by EEG recordings. This finding is in agreement with an earlier study that ketamine anesthesia prevents the mechanism of cortical spreading depression (Gorelova et al 1987).…”

Section: Cerebral Cortexsupporting

confidence: 83%

Responses to Tactile Stimulation in Deep Cerebellar Nucleus Neurons Result From Recurrent Activation in Multiple Pathways

Rowland¹,

Jaeger²

2008

Journal of Neurophysiology

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Rowland NC, Jaeger D. Responses to tactile stimulation in deep cerebellar nucleus neurons result from recurrent activation in multiple pathways. J Neurophysiol 99: 704 -717, 2008. First published December 12, 2007; doi:10.1152/jn.01100.2007. In a previous study, we found that neurons in the deep cerebellar nuclei (DCN) respond to 5-ms brief facial tactile stimulation in rats anesthetized with ketaminexylazine with multiphasic response patterns lasting over 200 ms. It remained unclear, however, to what extent these responses were shaped not only by ascending sensory input from the trigeminal nuclei but also by interactions with other major cerebellar afferent systems, in particular the inferior olive (IO) and cerebral cortex. In the present study, we recorded from the IO, cerebral cortex, cerebellar granule cell layer (GCL), and DCN during the presentation of 5-ms facial tactile stimuli to elucidate potential mechanisms of how extended DCN response patterns are generated. We found that tactile stimulation resulted in robust multiphasic local field potentials responses in the IO as well as in the activation of a wide region of the somatosensory cortex (SI) and the primary motor cortex (MI). DCN neurons responded to electrical stimulation of any of these structures (IO, SI, and MI) with complex temporal patterns strikingly similar to air-puff lip stimulation responses. Simultaneous recordings from multiple structures revealed that long-lasting activation patterns elicited in DCN neurons were based on recurrent network activation in particular between the IO and the DCN with a potential contribution of DCN rebound properties. These results are consistent with the hypothesis that sensory stimulation triggers a feedback network activation of cerebellum, IO, and cerebral cortex to generate temporal patterns of activity that may control the timing of behavior. I N T R O D U C T I O NIn the rat, sensory information from the face is conveyed from the trigeminal nuclear complex to the cerebellum through three principal pathways: direct trigeminocerebellar fibers, the inferior olive, and the somatosensory cortex via the basilar pontine nuclei (Waite and Tracey 1995). In a previous study, we demonstrated that stimulation of the orofacial region in anesthetized rats not only activates the cerebellar cortex (Bower and Woolston 1983;Shambes et al. 1978) but also produces reliable strong responses in the deep cerebellar nuclei (DCN) (Rowland and Jaeger 2005). Single units in the DCN responded to 5-ms air-puff stimulation of the lips with multiphasic and extended temporal activity patterns that were mostly invariant to stimulus parameters. These sensory-evoked responses could be described as a combination of three temporal components: a brief excitation comprising one or a few spikes with a mean latency of 10 Ϯ 0.9 (SD) ms, a strong inhibition at a mean latency of 18 Ϯ 1.25 ms, and a second prolonged excitation with a mean latency of 291 Ϯ 13.3 ms. Different combinations and different amplitudes of these response components were ...

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Section: Cerebral Cortexsupporting

confidence: 83%

Responses to Tactile Stimulation in Deep Cerebellar Nucleus Neurons Result From Recurrent Activation in Multiple Pathways

Rowland¹,

Jaeger²

2008

Journal of Neurophysiology

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“…Several experiments document the correlation between SD or SD-like electrophysiological changes and en hancement of the glucose utilization in the periph ery of ischemic lesions (Nedergaard and Astrup, 1986;Hasegawa et al, 1990). Glutamate or agonists of the glutamate receptor elicit SD (Van Harreveld, 1959;Lauritzen et al, 1988), and glutamate recep tor antagonists effectively inhibit SD (Goroleva et al, 1987;Lauritzen and Hansen, 1992;Nellgard and Wielock, 1992). Brain temperature is one of the fac tors influencing the occurrence of SD (Marshall, 1959).…”

Section: Discussionmentioning

confidence: 99%

Spreading Waves of a Reduced Diffusion Coefficient of Water in Normal and Ischemic Rat Brain

Hasegawa

Latour

Formato

et al. 1995

J Cereb Blood Flow Metab

111

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Summary: Using echo planar diffusion-weighted mag netic resonance imaging, we measured three-dimensional changes in the apparent diffusion coefficient (ADC) of water in eight contiguous coronal slices, encompassing the entire rat brain, before and after local cortical stimu lation. We applied chemical (potassium chloride applica tion; n = 6) and mechanical (needle stab; n = 4) stimu lations to the right posterior parietal rat cortex. In all animals in which potassium chloride or the needle stab was applied, a region of decreased ADC values to a mean of 0.45 ± 0.03 x 1O-5cm2/s occurred. These reduced ADC levels appeared in the posterior parietal cortex within 1 min after cortical stimulation and the change recovered within 1 min. Then a ripple-like movement of

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“…The GABA A receptor is now accepted as a common target for many general anesthetics (Campagna, et al, 2003, Garrett and Gan, 1998, Hara and Harris, 2002, but enhanced GABAergic transmission is unlikely to modulate CSD susceptibility since barbiturates do not suppress CSD (Brand, et al, 1998, Kitahara, et al, 2001, Van Harreveld and Stamm, 1953. Relevant for CSD suppression, however, are the NMDA subtype of glutamate receptors, inhibition of which potently reduces CSD speed and duration, and blocks CSD (Gorelova, et al, 1987, Hernandez-Caceres, et al, 1987, Marrannes, et al, 1988, Obrenovitch and Zilkha, 1996. Interaction with NMDA receptors has thus far been convincingly demonstrated for isoflurane and N 2 O. Isoflurane causes modest inhibition of NMDA receptors, likely via the noncompetitive glycine site (Carla and Moroni, 1992, Dickinson, et al, 2007, Solt, et al, 2006.…”

Section: Discussionmentioning

confidence: 99%

The impact of anesthetics and hyperoxia on cortical spreading depression

Kudo

Nozari

Moskowitz

et al. 2008

Experimental Neurology

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Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura. It negatively impacts tissue injury during stroke, cerebral contusion and intracranial hemorrhage. Susceptibility to CSD has been assessed in several experimental animal models in vivo, such as after topical KCl application or cathodal stimulation. Various combinations of anesthetics and ambient conditions have been used by different laboratories making comparisons problematic and differences in data difficult to reconcile. We systematically studied CSD susceptibility comparing commonly used experimental anesthetics (isoflurane, α-chloralose, urethane) with or without N 2 O or normobaric hyperoxia (100% O 2 inhalation). The frequency of evoked CSDs, and their propagation speed, duration, and amplitude were recorded during 2 hour topical KCl (1M) application. We found that N 2 O reduced CSD frequency when combined with isoflurane or urethane, but not α-chloralose; N 2 O also decreased CSD propagation speed and duration. Urethane anesthesia was associated with the highest CSD frequency that was comparable to pentobarbital. Inhalation of 100% O 2 did not alter CSD frequency, propagation speed or duration in combination with any of the anesthetics tested. Our data show anesthetic modulation of CSD susceptibility in an experimental model of human disease, underscoring the importance of proper study design for hypothesis testing as well as for comparing results between studies.

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Ketamine blockade of cortical spreading depression in rats

Cited by 117 publications

References 17 publications

Responses to Tactile Stimulation in Deep Cerebellar Nucleus Neurons Result From Recurrent Activation in Multiple Pathways

Responses to Tactile Stimulation in Deep Cerebellar Nucleus Neurons Result From Recurrent Activation in Multiple Pathways

Spreading Waves of a Reduced Diffusion Coefficient of Water in Normal and Ischemic Rat Brain

The impact of anesthetics and hyperoxia on cortical spreading depression

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