Effective interpersonal communication with parents plays a crucial role in providing support and minimizing emotional exhaustion among high school students. The objective of this study is to examine the relationship between interpersonal communication effectiveness and emotional exhaustion in high school students, with a specific focus on the potential moderating effect of gender. Utilizing a correlational quantitative approach and employing cluster random sampling, the study included a population of 356 high school students. Data collection involved the utilization of two scales: the Interpersonal Communication Scale (comprising 48 items with a high internal consistency of α = 0.951) and the Emotional Exhaustion Scale (consisting of 42 items with a strong internal consistency of α = 0.931). Through simple regression analysis, the findings revealed a significant negative association between interpersonal communication effectiveness and emotional exhaustion, with interpersonal communication accounting for 14.7% of the variance in emotional exhaustion. When examining the data from a gender perspective, the analysis demonstrated that female students reported higher levels of emotional exhaustion compared to their male counterparts. Further exploration indicated that the aspect of openness emerged as the primary contributor to emotional exhaustion among high school students.