Ketoconazole suppresses food restriction–induced increases in heroin self-administration in rats: Sex differences.

Carroll, Marilyn E.; Campbell, Una C.; Heideman, Paul D.

doi:10.1037/1064-1297.9.3.307

Cited by 85 publications

(57 citation statements)

References 73 publications

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“…Although a growing body of evidence suggests that females are more prone to drug self-administration than males (Alexander et al, 1978;Lynch and Carroll, 1999;Carroll et al, 2001;Cicero et al, 2003;Hu et al, 2004;Roth et al, 2004), we found no differences in the acquisition of male and female mice. However, it is noteworthy that choice accuracy for the morphine-reinforced arm of the maze reached a maximum in female WT mice, with over 95% of drug-reinforced responses for 4 out of 6 self-administration sessions.…”

Section: Discussioncontrasting

confidence: 93%

Brain Regional Fos Expression Elicited by the Activation of μ- but not δ-Opioid Receptors of the Ventral Tegmental Area: Evidence for an Implication of the Ventral Thalamus in Opiate Reward

David

Matifas

Gavello-Baudy

et al. 2007

Neuropsychopharmacol

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Both m-opioid receptors (MORs) and d-opioid receptors (DORs) are expressed in the ventral tegmental area (VTA) and are thought to be involved in the addictive properties of opiates. However, their respective contributions to opiate reward remain unclear. We used intracranial self-administration (ICSA) to study the rewarding effects of morphine microinjections into the VTA of male and female MORÀ/À and DORÀ/À mice. In brains of mice tested for intra-VTA morphine self-administration, we analyzed regional Fos protein expression to investigate the neural circuitry underlying this behavior. Male and female WT and DORÀ/À mice exhibited similar selfadministration performances, whereas knockout of the MOR gene abolished intra-VTA morphine self-administration at all doses tested. Naloxone (4 mg/kg) disrupted this behavior in WT and DOR mutants, without triggering physical signs of withdrawal. Morphine ICSA was associated with an increase in Fos within the nucleus accumbens, striatum, limbic cortices, amygdala, hippocampus, the lateral mammillary nucleus (LM), and the ventral posteromedial thalamus (VPM). This latter structure was found to express high levels of Fos exclusively in self-administering WT and DORÀ/À mice. Abolition of morphine reward in MORÀ/À mice was associated with a decrease in Fos-positive neurons in the mesocorticolimbic dopamine system, amygdala, hippocampus (CA1), LM, and a complete absence within the VPM. We conclude that (i) VTA MORs, but not DORs, are critical for morphine reward and (ii) the role of VTA-thalamic projections in opiate reward deserves to be further explored.

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Section: Discussioncontrasting

confidence: 93%

Brain Regional Fos Expression Elicited by the Activation of μ- but not δ-Opioid Receptors of the Ventral Tegmental Area: Evidence for an Implication of the Ventral Thalamus in Opiate Reward

David

Matifas

Gavello-Baudy

et al. 2007

Neuropsychopharmacol

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“…This apparent "treatment" effect of reducing drug intake and impulsivity for the drug was greater in females than males (Fig. 4c, d, Table 4) and was consistent with the sex differences (females > males) found in several other studies using behavioral approaches, such as adding nondrug rewards like SACC in monkeys (Cosgrove and Carroll 2003), access to a running wheel in rats (Cosgrove et al 2002), or pharmacological treatments (Campbell et al 2002;Carroll et al 2001b;Cosgrove and Carroll 2004). These results suggest that females are more sensitive to rewarding effects of drugs and to treatments than males, and they may be more reward sensitive and/or less responsive to aversive events than males.…”

Section: Discussionsupporting

confidence: 83%

Impulsivity as a behavioral measure of withdrawal of orally delivered PCP and nondrug rewards in male and female monkeys

et al. 2009

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“…Women begin cocaine use at a younger age than do men (Griffin et al, 1989) and can become addicted to abused substances, such as cocaine, opiates, and alcohol, faster than do men (Lex, 1991). Similarly, female rodents demonstrate quicker acquisition of cocaine, methamphetamine, and nicotine intravenous self-administration than do males (Caggiula et al, 2002;Carroll et al, 2001;Roth and Carroll, 2004). Thus, these data suggest that females may be more vulnerable to effects of drugs of abuse.…”

Section: Introductionmentioning

confidence: 63%

Estradiol-Induced Conditioned Place Preference may Require Actions at Estrogen Receptors in the Nucleus Accumbens

Walf

Rhodes

Meade

et al. 2006

Neuropsychopharmacol

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Intrinsic rewarding effects of estradiol (E 2 ) may underlie some of the sex differences that emerge postpuberty for the prevalence of drug use and behavioral responses to drugs, but the effects and mechanisms of E 2 for reward have not been well characterized. Conditioned place preference (CPP), as measured by the time spent on the nonpreferred/drug-associated side of the chamber, was utilized as a functional assay to investigate the effects and mechanisms of E 2 in the nucleus accumbens for reward. To determine whether intracellular estrogen receptors (ERs) are important for E 2 -induced CPP, rats were administered E 2 (10 mg; subcutaneously (s.c.)), which produced CPP in each experiment, and/or ER blockers, such as tamoxifen (Experiment 1), ICI 182,780 (Experiment 2), or antisense oligonucleotides targeted to ERs (Experiment 3). Experiment 1: E 2 significantly increased the time spent on the originally nonpreferred side of the chamber. Coadministration of tamoxifen (10 mg/kg; s.c.) attenuated effects of E 2 to produce a CPP, but tamoxifen alone, increased time spent on the nonpreferred side. Experiment 2: coadministration of ICI 182,780 (10 mg/ml) to the nucleus accumbens attenuated effects of E 2 to enhance CPP and did not produce a CPP when administered alone. Experiment 3: coadministration of s.c. E 2 with ER antisense oligonucleotides to the nucleus accumbens significantly decreased time spent on the nonpreferred side and expression of ERs in the nucleus accumbens compared to scrambled antisense oligonucleotides or saline vehicle administration. Thus, E 2 's rewarding effects may involve actions at ERs in the nucleus accumbens.

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Ketoconazole suppresses food restriction–induced increases in heroin self-administration in rats: Sex differences.

Cited by 85 publications

References 73 publications

Brain Regional Fos Expression Elicited by the Activation of μ- but not δ-Opioid Receptors of the Ventral Tegmental Area: Evidence for an Implication of the Ventral Thalamus in Opiate Reward

Brain Regional Fos Expression Elicited by the Activation of μ- but not δ-Opioid Receptors of the Ventral Tegmental Area: Evidence for an Implication of the Ventral Thalamus in Opiate Reward

Impulsivity as a behavioral measure of withdrawal of orally delivered PCP and nondrug rewards in male and female monkeys

Estradiol-Induced Conditioned Place Preference may Require Actions at Estrogen Receptors in the Nucleus Accumbens

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