Ketoprofen mesoporous silica nanoparticles SBA-15 hard gelatin capsules: preparation and in vitro/in vivo characterization

Abstract

SBA-15 is used to enhance the bioavailability of poorly soluble ketoprofen (KP) through stabilization of its amorphous state. Additionally, the current work provides a complete in vitro and in vivo study on preformulated KP-SBA-15 sample and formulated KP-SBA-15 in hard gelatin capsule. Loading of KP was done by a novel method called immersion-rotavapor method. KP was quantified by extraction and thermal gravimetric analysis (TGA). Characterization of the loaded SBA-15 sample was done by high resolution transmission electron microscopy (HRTEM), small angle X-ray diffraction (SAXRD), nitrogen adsorption/desorption isotherms, differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR) spectroscopy and dissolution profiles. The loaded sample was formulated in hard gelatin capsule. The anti-inflammatory and analgesic studies were carried out on 24 adult male albino rats. TGA and extraction results showed 54.4 wt% of drug incorporated. Characterization of KP-SBA-15 sample confirmed the successful encapsulation of KP into the carrier pores in a molecular amorphous state. Additionally, loading of KP did not affect the mesoporous internal structure. During the first 5 min, the dissolution study showed very high release rates; nearly 50% of KP was released. These results were reflected on the in vivo study resulting in 82% inhibition in edema after 1 h and maximum analgesia after 30 min from the administration of the formulated sample. SBA-15 mesoporous silica nanoparticle proved to be a very promising drug delivery carrier that can be used as a facile way to enhance the bioavailability of poorly soluble drugs.

Polydopamine and peptide decorated doxorubicin-loaded mesoporous silica nanoparticles as a targeted drug delivery system for bladder cancer therapy

“…The peaks at 1515 and 1409 cm −1 might result from the targeted ligand PEP. All the nanoparticles presented absorption peaks at 1075 cm −1 , which were caused by Si–O–Si stretching vibrations on MSNs network (Abd-Elrahman et al, 2016 ; Zhu et al, 2016 ).…”

Modification of the Release of Poorly Soluble Sulindac with the APTES-Modified SBA-15 Mesoporous Silica

“…Our results are in line with the previously reported data. In the spectra of the APTES-modified SBA-15, the bands around 3430 cm −1 and 1630 cm −1 are identified as the stretching and bending vibrations of the OH groups (Si–OH), respectively [ 31 ]. The broad band in the range 1200–1080 cm −1 can be assigned to the Si–O–Si asymmetric stretching vibrations.…”

Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential

“…They have claimed that the absence of the melting peak of doxycycline hyclate in the DSC curve resulted from the formation of an inclusion complex between drug molecules and β-cyclodextrin. Moreover, the disappearance of DSC peaks characteristic for melting points of other drugs such as aprepitant [ 33 ], ketoprofen [ 34 ], ticagrelor [ 35 ] have been reported for various mesoporous silicas and suggested both the successful encapsulation of drug molecules and their amorphous or semi-crystalline nature inside the pores.…”