“…Over many years research has been carried out to develop alternative novel drug delivery systems that would mimic the physiological environment by delivering insulin, in response to the blood glucose level. Formulations such as hydrogels, microcapsules, liposomes, and other soft technology systems as well as inserts and nanoparticles have been proposed (Taylor, Tanna, Taylor and Adams, 1995;Le Bourlais, Acar, Zia, Sado, Needham and Leverge, 1998;Gupta, Madan, Majumdar, and Maitra, 2000;Willoughby, Batterbury, and Kaye, 2002;Yadav, et. al., 2009;Adams, et.…”