Key factors in the regulation of fetal and postnatal leydig cell development

Wu, Xia; Wan, Shengqin; Lee, Mary

doi:10.1002/jcp.21231

Cited by 40 publications

(25 citation statements)

References 71 publications

(101 reference statements)

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“…During pubertal development, a number of factors influence LC differentiation and steroidogenesis (Ge et al 1996, Wu et al 2007. Androstanediol reflects metabolic enzyme activity and is the major androgen produced by immature rat LCs (Benton et al 1995, Ge & Hardy 1998).…”

Section: Discussionmentioning

confidence: 99%

“…By d56, the ILCs terminally differentiate into ALCs that still express type III 17bHsd abundantly (Ge & Hardy 1998), while the expression of androgen metabolizing enzymes is downregulated, thereby leading to the highest net production of testosterone (Shan et al 1993, Benton et al 1995, Viger & Robaire 1995. These stage-specific androgen profiles reflect the opposing actions of androgen biosynthetic and metabolizing enzymes (Shan et al 1993, Ge & Hardy 1998, Payne & Hales 2004, and demarcate maturational transitions in LC development and differentiation (Shan et al 1993, Ge et al 1996, Wu et al 2007.…”

Section: Introductionmentioning

confidence: 99%

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Androgen profiles during pubertal Leydig cell development in mice

Arumugam²,

Zhang³

et al. 2010

Reproduction

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Postnatal Leydig cell (LC) development in mice has been assumed empirically to resemble that of rats, which have characteristic hormonal profiles at well-defined maturational stages. To characterize the changes in LC function and gene expression in mice, we examined reproductive hormone expression from birth to 180 days, and quantified in vivo and in vitro production of androgens during sexual maturation. Although the overall plasma androgen and LH profiles from birth through puberty were comparable to that of rats, the timing of developmental changes in androgen production and steroidogenic capacity of isolated LCs differed. In mice, onset of androgen biosynthetic capacity, distinguished by an acute rise in androstenedione and testosterone production and an increased expression of the steroidogenic enzymes, cytochrome P450 cholesterol side-chain cleavage enzyme and 17a-hydroxylase, occurred at day 24 (d24) rather than at d21 as reported in rats. Moreover, in contrast to persistently high testosterone production by pubertal and adult rat LCs, testosterone production was maximal at d45 in mice, and then declined in mature LCs. The murine LCs also respond more robustly to LH stimulation, with a greater increment in LH-stimulated testosterone production. Collectively, these data suggest that the mouse LC lineage has a delayed onset, and that it has an accelerated pace of maturation compared with the rat LC lineage. Across comparable maturational stages, LCs exhibit species-specific developmental changes in enzyme expression and capacity for androgen production. Our results demonstrate distinct differences in LC differentiation between mice and rats, and provide informative data for assessing reproductive phenotypes of recombinant mouse models.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Androgen profiles during pubertal Leydig cell development in mice

Arumugam²,

Zhang³

et al. 2010

Reproduction

Self Cite

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“…This kind of matter could disrupt the formation and development of testis [8,29]. Isoflavone has received enormous attention as it has been demonstrated to be effective in many diseases and has another function as one of EDC due to its estrogenic effect [33,36].…”

Section: Satriyasa Et Almentioning

confidence: 99%

Changes in Male Reproductive System Induced by Tempeh Ethanol Extract Administered to Rats From Prenatal Until Weaning Period of Life

Satriyasa

Ni²,

Karmaya

2018

Asian J Pharm Clin Res

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Objective: Sertoli cell and spermatogonia are formed in the prenatal period, and alterations information process could affect the reproduction function in the adolescence and adult period. This study aimed to unveil the effect of tempeh's isoflavone that was given from prenatal to weaning during childhood period toward the amount of Sertoli cell and spermatogonia. Method:The study design was randomized post-test only control group design with 15 female Wistar experimental mouse in the aged of 12 th -13 th weeks was used and divided into three groups, namely, control groups (C) that were given aquadest, intervention Group 1 (I1) and intervention Group 2 (I2) that was given tempeh 0.5 g/kg body weight/day ethanol extract that contains 0.52 mg genistein and 5 g/kg body weight/day that contains 5.2 mg genistein, respectively. The intervention was given for a week before copulation, during pregnancy and lactation period. The observed parameters were Sertoli cell and spermatogonia of an early-born mouse. Result:The amount of Sertoli cell and spermatogonia were different between the three groups (p<0.05). The I2 group has the lowest amount of Sertoli cell and spermatogonia and shows a significant difference from the control group as well as I1 (p<0.05). Tempeh ethanol extract has a direct impact on reducing the amount of Sertoli cell to about 11% lower than control. It also affected the number of spermatogonia indirectly through its effect toward Sertoli cells. Conclusion:Intervention of tempeh ethanol extract to female Wistar experimental mouse from prenatal period to weaning child period could disturb the formation of Sertoli cell and spermatogonia of the early-born mouse.

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“…Moreover, the inhibitory effects of Müllerian Inhibiting Substance (MIS) and transforming growth factor-bs (TGF-bs) on FLCs steroidogenic activity in postnatal testis have been described (Wu et al, 2007).…”

Section: Age-dependent Activity Of Hsdsmentioning

confidence: 99%