Identifying a set of influential nodes is an important topic in complex networks which plays a crucial role in many applications, such as market advertising, rumor controlling, and predicting valuable scientific publications. In regard to this, researchers have developed algorithms from simple degree methods to all kinds of sophisticated approaches. However, a more robust and practical algorithm is required for the task. In this paper, we propose the EnRenew algorithm aimed to identify a set of influential nodes via information entropy. Firstly, the information entropy of each node is calculated as initial spreading ability. Then, select the node with the largest information entropy and renovate its l-length reachable nodes' spreading ability by an attenuation factor, repeat this process until specific number of influential nodes are selected. Compared with the best state-of-the-art benchmark methods, the performance of proposed algorithm improved by 21.1%, 7.0%, 30.0%, 5.0%, 2.5%, and 9.0% in final affected scale on CEnew, Email, Hamster, Router, Condmat, and Amazon network, respectively, under the Susceptible-Infected-Recovered (SIR) simulation model. The proposed algorithm measures the importance of nodes based on information entropy and selects a group of important nodes through dynamic update strategy. The impressive results on the SIR simulation model shed light on new method of node mining in complex networks for information spreading and epidemic prevention.Entropy 2020, 22, 242 2 of 19 diffusion [9], and even detect essential proteins [10]. On the other hand, by removing some critical nodes, it can greatly reduce the connectivity of the network to restrain the outbreak of epidemics [11] or spreading of rumors [12].The ongoing COVID-19 epidemics is catching wide attention around the world. Every country is making enormous effort to control the virus spreading. By analyzing social networks, it would be easier for us to control epidemics spreading. In the last decades, propagation dynamics has always been an important research direction. Many mechanisms, such as epidemic spreading [13][14][15][16], rumor propagation [17,18], social sudden events spreading [19], and e-commercial advertisements, are all closely related to complex network dynamics. Early in 1760, Daniel Bernoulli studied smallpox vaccine by using ordinary differential equations, and gave the Bernoulli equations [20] , which is one of the earliest propagation dynamics models. Later, Hamer presented the mass-action principle [21,22] when studying the recurring epidemics of measles. A.G. McKendrick and W.O. Kermack formulated a famous modern mathematical epidemic model named the Susceptible-Infected-Recovered (SIR) compartmental model when studying the spreading pattern of the Black Death and the plague in 1906. SIR compartmental model successfully predicted the outbreak of several epidemics [23]. Harding et al. [24] followed the maximum entropy (MaxEnt) principle when simulating on the SIS model to study epidemics spreading on networks. Wang et ...