Key oncologic pathways inhibited by Erinacine A: A perspective for its development as an anticancer molecule

Prasher, Parteek; Sharma, Mousmee; Sharma, Amit; Sharifi‐Rad, Javad; Călina, Daniela; Hano, Christophe; Cho, William C.

doi:10.1016/j.biopha.2023.114332

Cited by 13 publications

(5 citation statements)

References 49 publications

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“…MAPK mitogen-activated protein kinase (MAPK) pathway is vital for the adaptation of the cell to stress and its activation is highly involved in the inflammation process ( Motyka et al, 2023 ; Prasher et al, 2023 ). The cell inflammation induction by lipopolysaccharide (LPS) triggers a series of signaling pathways including MAPK and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) ( Li et al, 2016 ; Capó et al, 2021 ; Pezzani et al, 2023 ).…”

Section: Anticancer Mechanisms and Targeting Signaling Pathways By Al...mentioning

confidence: 99%

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

et al. 2023

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Alternariol is a toxic metabolite of Alternaria fungi and studies have shown multiple potential pharmacological effects. To outline the anticancer effects and mechanisms of alternariol and its derivatives based on database reports, an updated search of PubMed/MedLine, ScienceDirect, Web of Science, and Scopus databases was performed with relevant keywords for published articles. The studies found to suggest that this mycotoxin and/or its derivatives have potential anticancer effects in many pharmacological preclinical test systems. Scientific reports indicate that alternariol and/or its derivatives exhibit anticancer through several pathways, including cytotoxic, reactive oxygen species leading to oxidative stress and mitochondrial dysfunction-linked cytotoxic effect, anti-inflammatory, cell cycle arrest, apoptotic cell death, genotoxic and mutagenic, anti-proliferative, autophagy, and estrogenic and clastogenic mechanisms. In light of these results, alternariol may be one of the hopeful chemotherapeutic agents.

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Section: Anticancer Mechanisms and Targeting Signaling Pathways By Al...mentioning

confidence: 99%

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

et al. 2023

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“…Anticancer activity of fungal metabolites: The study of the anticancer activity of fungal metabolites is a rapidly growing field, involving the evaluation of various compounds from fungal sources, their mechanisms of action, and biosynthetic pathways on cancer cells [ 72 , 82 , [111] , [112] , [113] , [114] , [115] , [116] ]. Fungi produce a diverse array of bioactive compounds, including, terpenes, polyphenols, and alkaloids, many of which exhibit significant anticancer activity and can serve as candidates or lead compounds for novel anticancer drugs [ 114 , [117] , [118] , [119] , [120] , [121] ]. The mechanisms by which fungal metabolites exhibit anticancer activity are diverse, and they affect various signaling pathways and molecular targets of cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…Induction of apoptosis by fungal metabolites: The induction of apoptosis by fungal metabolites has become a rapidly growing field in natural product drug discovery with promising potential for cancer prevention and treatment [ 72 , 143 ]. This field focuses on understanding the compounds produced by fungi that have the ability to induce self-regulated death of cancer cells, as well as their mechanisms of action and biosynthetic pathways [ 72 , 82 , [111] , [112] , [113] , [114] , [115] , [116] , 144 ]. The mechanisms by which fungal metabolites induce apoptosis in cancer cells are diverse and involve various signaling pathways and molecular targets.…”

Section: Discussionmentioning

confidence: 99%

Visualization of the relationship between fungi and cancer from the perspective of bibliometric analysis

Xu¹,

Zeng²,

Yu³

et al. 2023

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“…Cancer occurs as a result of somatic mutations in the cells that make up tissues [128][129][130]. Random mutations that constantly accumulate without having a negative impact on cell survival are passenger mutations and they do not cause clonal expansion of a malignant transformed cell, they do not promote tumour growth instead driver mutations cause oncogenesis [131,132].…”

Section: Anti-mutagenicmentioning

confidence: 99%

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

et al. 2023

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Paeoniaemodi Wall. ex Royle is commonly known as Himalayan paeony has great importance as a food and medicine. The practice of Paeoniaemodi Wall. ex Royle is very ancient and it is conventionally used for a wide range of illnesses in the folk system of medicine because of its wide beneficial phytochemical profile. The main purpose of the current review was the synthesis of recent data on botany, ethnopharmacology, phytochemistry and potential pharmacological mechanisms of action of Paeoniaemodi Wall. ex Royle, thus offering new prospects for the development of new adjuvant natural therapies. Using scientific databases such as PubMed/MedLine, Scopus, Web of Science, ScienceDirect, Google Scholar, Springer, and Wiley, a comprehensive literature search was performed for Paeoniaemodi Wall. ex Royle. For searching, we used the next MeSH terms: “Biological Product/isolation and purification”, “Biological Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. The results of the most recent studies were analyzed and the most important data were summarized in tables and figures. Phytochemical research of Paeoniaemodi Wall. ex Royle has led to the isolation of triterpenes, monoterpenes, phenolic acids, fatty acids, organic compounds, steroids, free radicals and some other classes of primary metabolites. In addition, diverse pharmacological activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase and beta-glucuronidase inhibiting activity, radical scavenging activity, phytotoxic and insecticidal activities have been reported for Paeoniaemodi Wall. ex Royle. Different bioactive compounds of Paeoniaemodi Wall. ex Royle has proven their therapeutic potential in modern pharmacological and biomedical research to cure numerous gastrointestinal and nervous disorders. In future, further in vitro and in vivo therapeutic studies are required to identify new mechanisms of action, pharmacokinetics studies, and new pharmaceutical formulations for target transport and possible interaction with allopathic drugs. Also, new research regarding quality evaluation, toxicity and safety data in humans is needed.

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Key oncologic pathways inhibited by Erinacine A: A perspective for its development as an anticancer molecule

Cited by 13 publications

References 49 publications

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms

Visualization of the relationship between fungi and cancer from the perspective of bibliometric analysis

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

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