Key Roles of Reactive Oxygen and Nitrogen Species

Graves, David B.; Bauer, Georg

doi:10.1007/978-3-319-67627-2_4

Cited by 10 publications

(7 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hydroxyl radicals, ions, electrons, photons, ionized gas, and very small amount of ultraviolet light emitted from plasmas are harmless to the human body. Moreover, nitric oxide radicals produced when plasma is generated using nitrogen gas has been found to promote cell differentiation and wound healing [6][7][8][9][10]. In animal models, researchers have found that these radicals are effective against tissue infections and acute and chronic inflammation.…”

Section: Resultsmentioning

confidence: 99%

New Concept of Plasma-Forming : PLASMA Physics for Your Skin Treatment

Choi

2020

Korean Association For Laser Dernatology And Trichology

View full text Add to dashboard Cite

The elements that form the Earth appear in the form of solids, liquids, and gases, transitioning between states thereof with changes in temperature. When there is more energy applied to these three basic state, it becomes the plasma. A plasma is formed when there are equal amounts of ionized particles and electrons, called a quasi-neutral state. Plasma with various properties is used in various applied sciences, industries, and medical fields. When artificially generated plasma is used for industrial or medical use, it can be divided into high temperature or thermal plasma and cold plasma according to the temperature. High-temperature plasma is mainly used for industrial purposes such as nuclear fusion, incineration, and metal cutting, whereas low-temperature plasma is used for light-emitting sources, medical fields, and equipment. The most typical characteristic of plasma is the radicals that are generated in various ways. the radicals generated by plasmas are thought to be more effective in killing cancer cells or sterilizing bacteria. Various radicals generated in the plasma destroy the cell wall of bacteria and have a strong sterilizing effect and interestingly, living tissues are hardly damaged under the same conditions. Therefore, plasma has a very good effect on bacterial-infected tissues, thereby can speed up the wound healing process. In particular, interest in plasma for dermatological treatment is increasing, and cases of use for wound healing have been reported in the UK and Germany. In addition, recently, cases of use in acne, athlete's foot, freckles, and atopy have been continuously reported, and as interest in plasma has increased, efforts to apply it to various skin treatments are increasing. Plasma will continue to be actively researched in more fields in the future. Through such efforts, it will be necessary to develop purpose-built plasma generating devices that are easier and more convenient to use. Furthermore, additional research is needed to determine how unstable plasma energy can be accurately adjusted and to develop quantitative methods with which to measure radicals present in a plasma.

show abstract

Section: Resultsmentioning

confidence: 99%

New Concept of Plasma-Forming : PLASMA Physics for Your Skin Treatment

Choi

2020

Korean Association For Laser Dernatology And Trichology

View full text Add to dashboard Cite

show abstract

“…Due to the exposure to NO 2 , the higher chemicals level in the forms of gas and particles may lead the air pollution to cause oxidative stress and inflammation (18)(19). During this condition, the body's response to the free radical pollution will produce ROS and RNS, which harm the proteins, lipids, and DNA.…”

Section: Discussionmentioning

confidence: 99%

Nitrogen Dioxide Concentrations in the Air in Increasing Superoxide Dismutase Enzyme and Malondialdehyde Serum Levels in Bus Terminal Officers

Kahar

Sulistyorini

Keman

2021

JKL

View full text Add to dashboard Cite

Introduction: Free radicals in the air such as NO2 , O3 , PM2,5 induce the production of reactive oxygen species (ROS) in the body and stimulates the production of superoxide dismutase (SOD) enzyme. Imbalanced levels of free radicals and antioxidants will trigger the production of malondialdehyde (MDA). This study aimed to analyze the correlation between NO2 concentrations in the air with SOD and MDA levels in bus terminal officers. Methods: This study was an analytical observational and used a cross-sectional design. The population included terminal operational officers and desk administrative officers in the bus terminal. A number of 12 people was chosen as a sample calculated with averaging formula between case and control. The measurement of NO2 concentrations in the ambient air was performed using the Griess Saltzman method. The ELISA method was utilized to analyze the levels of the SOD enzyme, and the TBARS method was used to analyze the level of MDA serum. A statistical test was conducted using a Mann-Whitney test and Independent-2 Sample T-test. Results and Discussion: The average of NO2 concentrations in the ambient air showed 106.5 µg/Nm3 and in the administration room at 17.8 µg/Nm3 . There was a very significantly higher exposure to NO2 in the air towards the level of SOD enzyme (p < 0.01) and to the level of MDA serum (p < 0.01). Conclusion: The high level of exposure to NO2 in the ambient air will increase SOD enzyme and MDA serum production in the body. It is recommended that the officers consume more fruit and vegetables containing vitamins C and E to fulfill the daily nutritional intake for antioxidants, and for the operational officers, always use a mask

show abstract

“…However, further increases of RONS caused by PAAWM treatment influence cellular natural oxidation-reduction, trigger and initiate mitochondrial damage, growth inhibition, and apoptosis in a dose-dependent manner. [2,22] Aquaporins are abundant in cancer cells, facilitate the diffusion of RONS, and may be induced (aquaporin 4) upon exposure to reactive oxygen species. [46][47][48] In mammalian cells, aquaporins 1, 3, and 8 were found to mediate H 2 O 2 cellular uptake.…”

Section: Two Hepatocellular Carcinoma Cell Lines (Snu-449 Andmentioning

confidence: 99%

“…[20,21] The reactive oxygen and nitrogen species (RONS) have a crucial role in the efficacy of CAP in cancer treatment through perturbation of the cellular natural redox reactions. [22] Intracellular cellar oxidative stress, aquaporins expression, and cell membrane content of cholesterol are the main elements that contribute to the CAP selective killing of malignant cells compared with normal cells of the same tissue. [23] Worldwide, hepatocellular carcinoma (HCC) is the fifth most common cancer and occupies second place in cancer deaths.…”

mentioning

confidence: 99%

Treatment of hepatocellular carcinoma with in situ generated plasma‐activated air‐driven water mist

Saadawy

Fathi

Elsayed

et al. 2023

Plasma Processes & Polymers

View full text Add to dashboard Cite

Since the development of cold atmospheric plasma (CAP), substantial and significant usage of CAP applications was introduced in medicine. Here, we developed two combined sources of plasma to produce in situ plasma‐activated air‐driven water mist (PAAWM). The first is generated using air as a feed gas, while the second is plasma‐activated water generated by the ignition of plasma within the air‐driven water mist. Both contribute to the plasma jet generation of PAAWM. The antitumor efficacy of PAAWM was evaluated against two hepatocellular carcinoma cell lines (SNU‐449 and SNU‐475). The generated PAAWM was efficient in the treatment of both chemosensitive and chemoresistant hepatocellular carcinoma cells. These results may support using PAAWM alone or in combination with other treatment modalities.

show abstract

Key Roles of Reactive Oxygen and Nitrogen Species

Cited by 10 publications

References 48 publications

New Concept of Plasma-Forming : PLASMA Physics for Your Skin Treatment

New Concept of Plasma-Forming : PLASMA Physics for Your Skin Treatment

Nitrogen Dioxide Concentrations in the Air in Increasing Superoxide Dismutase Enzyme and Malondialdehyde Serum Levels in Bus Terminal Officers

Treatment of hepatocellular carcinoma with in situ generated plasma‐activated air‐driven water mist

Contact Info

Product

Resources

About