Keys to successful management of patients with allergic rhinitis: Focus on patient confidence, compliance, and satisfaction

Marple, Bradley F.; Fornadley, John A.; Patel, Alpen A.; Fineman, Stanley; Fromer, Leonard; Krouse, John H.; Lanier, Bob; Penna, Pete

doi:10.1016/j.otohns.2007.02.031

Cited by 126 publications

(126 citation statements)

References 110 publications

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“…Allergic rhinitis (AR) is a common disorder that affects up to 50-60 million persons in the U.S, 1 accounting for 10%-40% of the population. 2 There is also strong evidence that the incidence may be increasing.…”

Section: Introductionmentioning

confidence: 99%

“…3 Given this high prevalence and the significant impact on quality of life, AR has been classified as a major chronic respiratory disease 4 and is now the 2nd leading cause of chronic disease in the United States. 1 The characteristic symptoms of allergic rhinitis are nasal congestion, sneezing, anterior and posterior nasal drainage, nasal itching and itchy/red/watery eyes. Patients may also complain of throat clearing, facial discomfort or headache, postnasal drip, or itchy throat and/or palate.…”

Section: Introductionmentioning

confidence: 99%

“…Patients may also complain of throat clearing, facial discomfort or headache, postnasal drip, or itchy throat and/or palate. 1,[4][5][6] Patients may also experience snoring, sleep disturbance, or fatigue and there is evidence that many patients may have decreased sense of sexual function. 7 The treatment of AR can lead to improvements in the specific allergic symptoms, enhancing overall quality of life and potentially reducing the incidence and/or severity of a number of comorbid disorders including asthma, rhinosinusitis, eustacian tube dysfunction and otitis media, allergic conjunctivitis, sleep disorders 4,6,8 and may improve sexual function.…”

Section: Introductionmentioning

confidence: 99%

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Montelukast: Pharmacology, Safety, Tolerability and Efficacy

Benninger

Waters

2009

Clinical Medicine. Therapeutics

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Allergic rhinitis and asthma are common disorders effecting large percentages of the population of Western countries. There are multiple treatment options available for allergic rhinitis and asthma and stepwise approaches to therapy have been recommended. Montelukast is a cysteinyl leukotriene receptor antagonist that has been found to be effective both in the treatment of allergic rhinitis and asthma. This paper will describe the pharmacology, safety, efficacy and tolerability of montelukast. It will examine the comparative efficacy of montelukast to other medications for the treatment of allergic rhinitis and asthma, as well as discuss the recent studies of combination therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Montelukast: Pharmacology, Safety, Tolerability and Efficacy

Benninger

Waters

2009

Clinical Medicine. Therapeutics

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“…Topical administration is also associated with a faster onset of action and lower incidence of systemic side effects. 20 Azelastine is a second generation antihistaminic. This H1 blocker has good topical activity in addition inhibits histamine release and inflammatory reaction triggered by leukotriene and platelet activating factor; and has a bronchodilator property.…”

Section: Introductionmentioning

confidence: 99%

Comparative clinical evaluation of effect of topical verses systemic anti -allergic drug in allergic rhinitis: a prospective study

Bhadouriya¹,

Srivastava

Saxena³

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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INTRODUCTIONThe term 'allergy', coined by von Pirquet, he proposed the term allergy, to describe a change of the living tissues, with increased or reduced sensitiveness due to the formation of specific antibodies.1 On exposure to the foreign protein the allergen combines with cell-bound reagenic antibodies to release histamine and similar amines and other factors.2 Allergy is used to define the series of events which occurs when an antigen, which is not harmful in itself, causes an immune response, leading to symptoms and disease in genetically predisposed individuals. The various manifestations of atopy and allergy are allergic rhinitis, allergic asthma, allergic conjunctivitis, allergic dermatitis, drug allergies, bee stings and urticaria/angioedema. Nasobronchial allergies i.e. asthma or rhinitis alone or asthma with rhinitis are the commonest allergic manifestations with 75.4% of patients belonging to this group. 3 Vangham and Bray stated that roughly 10% of general population is frankly allergic and 50% given history of transient episodes. 4 Allergic rhinitis is the most common allergy encountered in clinical practice and constitutes about 55% of allergies seen in India 5 .Shambough stated that at least 90% of chronic nasal infections and 70% of chronic sinus ABSTRACT Background: Nasal passages form one of the chief sources of contact of the human with his environment. Hence, it is natural that the mucosa of the area is the victim of assault with multitudes of potential allergens. Allergic rhinitis is an inflammatory disease with worldwide prevalence of 10-40%. Allergic rhinitis is a disease with low mortality but significantly lowers the quality of life and functioning. Both oral and intranasal antihistamines are approved for the first-line treatment of allergic rhinitis and both formulations result in a reduction in symptoms and an improvement in quality of life. Methods: The following study was designed to assess the efficacy and safety of the azelastine nasal spray in comparison to levocetrizine in patients with allergic rhinitis. Out of the 68 patients, 34 cases were treated with topical azelastine (group A), while remaining 34 with systemic levocetrizine (group B). The effects of anti-allergic drugs have been studied on the basis of relief of symptoms and change in histopathology. Results: The effect of levocetrizine has been studied on the basis of relief of symptoms and change in histopathology and found to have complete response in 58% and fair response in 23.5% patients of allergic rhinitis. The effect of topical azelastine nasal spray have complete response in 70.5% and fair response in 23.5% patients of allergic rhinitis. Conclusions: Comparing the post therapy clinical and histopathological results in this study, azelastine nasal spray was found to be more effective and safe in the treatment of allergic rhinitis than levocetrizine.

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“…AR is characterized by sneezing, rhinorrhea, nasal discharge, nasal congestion, itchy/watery eyes and headaches. The most bothersome symptoms are sneezing, runny nose, itching and nasal congestion [2][3][4]. However, chronic rhinitis symptoms do not mean allergy every time.…”

Section: Introductionmentioning

confidence: 99%

Sneezing and Runny Nose: Should Allergy Testing Be Routinely Performed?

Can

İslam

Taştan

et al. 2011

Indian J Otolaryngol Head Neck Surg

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The need for routine determination of rhinitis subtypes by allergy testing and the relevance between symptoms and allergy were evaluated. A retrospective study at a tertiary hospital, ENT clinic. One hundred and twentyseven adult patients with sneezing and runny nose for at least 6 months for the last two consecutive years were included. The age range was 16-60. Allergy testing was only positive in 43.4% of the patients. Excluding mixed rhinitis, persistent sneezing and runny nose were mostly related to anatomical deformities, mainly septal deviation followed by vasomotor rhinitis. Persistent sneezing and runny nose may be caused by different etiologies other than allergy. Determination of rhinitis subtypes is important for accurate treatment of patients with these symptoms. Taking appropriate medical history and performing a good physical exam with objective allergy testing are highly recommended.

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Keys to successful management of patients with allergic rhinitis: Focus on patient confidence, compliance, and satisfaction

Abstract: Health care providers must gain a greater understanding of patient expectations to increase medication compliance and patient satisfaction and confidence.

Cited by 126 publications

References 110 publications

Montelukast: Pharmacology, Safety, Tolerability and Efficacy

Montelukast: Pharmacology, Safety, Tolerability and Efficacy

Comparative clinical evaluation of effect of topical verses systemic anti -allergic drug in allergic rhinitis: a prospective study

Sneezing and Runny Nose: Should Allergy Testing Be Routinely Performed?

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